Senior Research Scientist
Biophysical Characterization and Developability Assessment
Confirmed live in the last 24 hours
AbCellera Biologics

501-1,000 employees

Accelerates antibody drug discovery with data science
Company Overview
AbCellera stands out as a leader in the biotech industry due to its unique approach to antibody drug discovery, combining expert teams, advanced technology, and data science to expedite the process from target to clinic across various therapeutic areas. The company's competitive edge lies in its ability to enable swift progress, cost reduction, and problem-solving in drug development for both innovative biotechs and leading pharmaceutical companies. Furthermore, AbCellera's commitment to technical innovation is evident in its recent presentation of new data on two T-Cell Engager Programs at SITC 2023, demonstrating its active role in advancing the field.
AI & Machine Learning
Data & Analytics
Biotechnology

Company Stage

Series A

Total Funding

$393.7M

Founded

2012

Headquarters

Vancouver, Canada

Growth & Insights
Headcount

6 month growth

-2%

1 year growth

17%

2 year growth

79%
Locations
Vancouver, BC, Canada
Experience Level
Entry
Junior
Mid
Senior
Expert
Desired Skills
Data Science
CategoriesNew
Lab & Research
Life Sciences
Requirements
  • PhD in Biophysics, Biochemistry, or Structural Biology
  • 8+ years of relevant experience including at least 4 years in the biopharma or biotechnology industries
  • Demonstrated expertise in the evaluation of protein interactions and mechanism of action using SPR, BLI, ITC, ELISA, Kinexa, AUC, or related technologies
  • Experience applying analytical SEC, HIC, IEX, light scattering, CE-SDS, cIEF, DSF, DSC, mass spectrometry, or related techniques to assess sample quality and developability of biotherapeutics
  • In-depth understanding of antibody sequences and structure, as well as common modifications and physical and chemical stability risks
  • Experience managing and interacting with electronic lab notebook environments, and laboratory information and inventory management systems
  • Strong interpersonal skills with the ability to work collaboratively as a member of a cross-functional team
  • Excellent decision-making and troubleshooting skills, as well as effective documentation and organizational skills with a high attention to detail
  • Comfortable writing formal reports with interpretations based on data generated in complex biological systems to build mechanistic confidence in a target
  • Self-motivated, and have the initiative to meet project goals under tight timelines
Responsibilities
  • Providing leadership in the application of biophysical characterization methods to assess the binding interactions and developability of biotherapeutics
  • Establishing strategy, developing workflows, and integrating new technologies to assess antibody binding properties including kinetics, affinity, epitope, and mechanism of action, to identify promising therapeutic candidates
  • Designing and executing detailed early formulation and stability studies to identify developable lead molecules
  • Analyzing and interpreting complex data sets including analytical, biophysical, binding, and in silico assessments, to nominate lead candidate antibody molecules to progress into clinical development
  • Providing protein science and biotherapeutic leadership within multidisciplinary drug discovery program teams
  • Mentoring junior scientists within a rapidly growing and dynamic team
  • Collaborating with teammates to leverage automation, data science, bioinformatics and machine learning to expand the throughput of antibody screening, including data curation, analysis and interpretation of large data sets
  • Acting as a subject matter expert for antibody developability and biophysical characterization