Full-Time

Junior Engineer

Bioreactors

Retro Biosciences

Retro Biosciences

51-200 employees

Develops aging-focused therapeutics across programs.

Compensation Overview

$110k - $130k/yr

San Carlos, CA, USA

In Person

Category
Biology & Biotech (3)
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Required Skills
Mechatronics
Requirements
  • A degree in biomedical engineering, mechanical engineering, electrical engineering, mechatronics, or equivalent hands-on experience.
  • Proven experience building and assembling hardware systems (not only designing)—especially where precision and repeatability matter (instrumentation, precision manufacturing, hardware R&D, etc.).
  • Strong mechanical aptitude (comfortable reading manuals/schematics, diagnosing failures, working with fittings/tubing/fluid paths).
  • Comfort working across disciplines (fluidics, sensors, electronics, mechanical assemblies) and learning new skills quickly.
  • Great organizational skills and attention to detail—able to keep systems, logs, and procedures clean and reliable in a fast-moving lab environment.
  • A love of complex systems and machines, the ability to troubleshoot on the fly, and the desire to continuously improve processes.
  • Pride in your work - you don’t wait around for a work order when you notice a problem, you feel ownership of the labs’ well-being.
Responsibilities
  • Assemble and maintain custom-built bioreactors producing cutting edge cell therapies (combination of fluidics, electronics).
  • Source and modify the right parts (fittings, electronics, fluidics) for bioreactor building and expansion.
  • Own pre-experiment setup readiness, including sterilization/autoclave workflows, sterile assembly, and end-to-end system preparation.
  • Develop repeatable build/assembly processes (fixtures, checklists, standards) to reduce setup time and variability across runs.
  • Troubleshoot and resolve hardware/software issues quickly (leaks, pressure/flow instability, sensor drift, electrical faults, controller errors).
  • Support in-experiment operations by monitoring sensors, pressure, weights, and media changes, and responding rapidly to deviations.
  • Implement and improve process monitoring and control strategies to maintain optimal cell culture environments.
  • Partner with process development scientists to integrate bioreactor systems into workflows and scale experimental throughput.
  • Train lab personnel on proper instrument use and best practices; update workflows and SOPs as systems evolve.
  • Produce and maintain rigorous documentation and records (maintenance logs, calibrations, QC checks, SOPs, and design documentation) to support internal knowledge sharing, regulatory submissions, and GMP transition.
Desired Qualifications
  • Worked with bioreactors and/or automation equipment.
  • Worked with equipment in a GMP environment.
  • Experience sourcing parts and coordinating with vendors (e.g., McMaster-Carr and similar suppliers); ability to quickly find, evaluate, and procure the right components.
  • Basic programming or scripting skills for instrument control or data analysis.
  • Basic electronics skills (circuits, breadboards, microcontrollers, sensors, displays).
  • 3D printing and rapid prototyping experience.
  • Worked in startup or “scrappy build” environments where requirements evolve quickly.

Retro Biosciences develops therapeutics aimed at extending healthy human lifespan by addressing the cellular drivers of aging. The company runs three main programs—cellular reprogramming, plasma-inspired therapeutics, and autophagy—supported by single-cell multi-omics, computational biology, and lab automation to build a pipeline that targets aging mechanisms to prevent multiple age-related diseases. Revenue comes from developing and commercializing these candidates once they prove concept through research and clinical development. The company differentiates itself by focusing on root causes of aging rather than single-disease drugs, using diverse, technology-enabled programs with a balanced pipeline, and leveraging advanced analytics and automation to accelerate discovery. The goal is to extend healthy years of life by ten years and reduce the healthcare burden from aging-related diseases.

Company Size

51-200

Company Stage

Series A

Total Funding

$1.2B

Headquarters

Redwood City, California

Founded

2021

Simplify Jobs

Simplify's Take

What believers are saying

  • $85M Multiply Labs deal automates cell therapy scaling for rapid trials.
  • MCRI partnership develops autologous HSC therapies eliminating donor mismatches.
  • OpenAI GPT-4b micro boosts stem cell markers and DNA repair in aged cells.

What critics are saying

  • Altos Labs' $3B funding captures talent, outpaces Retro's $1B Series A.
  • RTR242 Phase 1 fails safety in Australia by end-2025 from off-target effects.
  • Yamanaka reprogramming triggers tumors, halting programs per OSKM studies.

What makes Retro Biosciences unique

  • Retro Biosciences pioneers AI-redesigned Yamanaka factors achieving 50-fold reprogramming efficiency.
  • RTR242 pill reboots autophagy to clear brain proteins unlike amyloid plaque flushers.
  • Diversified pipeline balances autophagy, plasma, and HSC reprogramming programs.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

401(k) Retirement Plan

401(k) Company Match

Unlimited Paid Time Off

Paid Holidays

Parental Leave

Professional Development Budget

Growth & Insights and Company News

Headcount

6 month growth

-6%

1 year growth

-5%

2 year growth

-4%
Epium Limited
Mar 14th, 2026
Sam Altman backed Retro Biosciences tests longevity pill targeting brain aging

Sam Altman backed Retro Biosciences tests longevity pill targeting brain aging. Retro Biosciences, funded by OpenAI chief executive Sam Altman, is preparing its first human trial of a pill that aims to clear damaged proteins in the brain by rebooting cellular recycling linked to Alzheimer's and Parkinson's. Retro Biosciences, a longevity startup backed by OpenAI chief executive Sam Altman, is preparing to launch its first human clinical trial by the end of 2025 for an experimental small molecule pill called RTR242. The company was founded in 2021 with an initial 180 million investment from Altman and is led by chief executive Joe Betts-LaCroix, a scientist and entrepreneur who previously helped build what was described as the world's smallest computer. Retro's overarching ambition is to decouple aging from decline and disease by developing therapies that reset key aspects of human biology to a more youthful state and add 10 extra, healthy years to human lifespan. RTR242 is intended to treat Alzheimer's by reviving autophagy, the cellular recycling process that is activated by fasting and is widely believed to have broad antiaging effects. Betts-LaCroix described how "old, misfolded, mutated, broken, undigestible proteins inside cells" accumulate over time as "the normal cellular recycling system gets messed up." The pill is designed to clear "gunk in the cells" associated with Alzheimer's and Parkinson's and, if effective, could restart stalled autophagy pathways and clean up damage "especially in the brain cells." In contrast to newer Alzheimer's drugs such as Eisai's Leqembi and Eli Lilly's Kisunla, which slow cognitive decline by flushing out amyloid plaques, Retro is focused on therapeutics that aim to reverse aspects of aging rather than simply slow them. The company is in "hardcore preclinical mode" and has chosen Australia for its Phase 1 safety trial because it is faster and easier to initiate such studies there, with a trial site and lab vendors already selected and first participant enrollment expected toward the end of the year. Retro is also advancing two other major programs: RTR890, a treatment for blood diseases like leukemia that would generate fresh blood stem cells from a patient's own cells, and RTR888, a stem cell derived therapy targeting diseases of the central nervous system. To fund large scale clinical development, Retro aims to raise 1 billion in a Series A round, which would place it closer to rivals like Jeff Bezos backed Altos Labs, reported to have raised more than 3 billion from prominent tech investors. While some in the field, such as Gero founder Peter Fedichev, question whether a 10 year gain in healthy lifespan can be achieved through lifestyle alone, Betts-LaCroix argues that "curing cancer would add about three years to life expectancy, and curing heart disease about four," and that adding 10 healthy years "will be an even greater impact." Alongside its drug pipeline, Retro is exploring more radical longevity approaches through a partnership with OpenAI on protein design. In August, OpenAI described a custom "GPT-4b micro" protein designing Artificial Intelligence model developed with Retro, stating that GPT-4b micro improved the expression of stem cell reprogramming markers 50-fold compared with natural reprogramming factors. Cellular reprogramming, which seeks to reverse cellular aging and engineer new tissues for older bodies, is seen as one of Silicon Valley's most ambitious longevity bets. Betts-LaCroix says Retro aims to balance a traditional pharmaceutical strategy, focused on single diseases and acquirable drug programs like RTR242, with bolder attempts to "reset some aspect of our biology back to essentially a younger age." For now, Retro is moving cautiously with its first clinical trial while keeping options open for more transformative technologies powered by advances in Artificial Intelligence driven protein engineering. 55. March 14, 2026 New research comparing 178 countries finds Europe far ahead in comprehensive Artificial Intelligence regulation, while the United Kingdom and United States trail not only the European Union but also Kazakhstan. March 13, 2026 Yann LeCun is backing a world model approach to Artificial Intelligence with a $1.03B seed round, while Nvidia commits at least a gigawatt of compute to Mira Murati's Thinking Machines in a multiyear deal. March 13, 2026 The United States Central Command is using advanced artificial intelligence systems to rapidly process battlefield data in the joint US-Israeli campaign in Iran, while insisting that humans retain final authority over targeting decisions. March 13, 2026 A new optical compute interconnect consortium led by major chip and cloud companies aims to define an open specification for scale-up links in modern artificial intelligence infrastructure, shifting away from copper limitations. March 13, 2026 Nvidia and Dassault Systèmes are combining accelerated computing, physics-based world models and virtual twins to speed up design, simulation and deployment across sectors from automotive to life sciences and aerospace.

AZoNetwork
May 19th, 2025
New partnership aims to advance treatments for blood disorders and leukemia

MCRI, a flagship member of the Melbourne Biomedical Precinct and the Melbourne arm of the international research consortium, the Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, has today announced a significant research and commercial licensing agreement with Retro Biosciences.

Bioengineer.org
May 19th, 2025
New $35M US Partnership to Propel Breakthroughs in Blood Disorder Treatments

By integrating MCRI's cutting-edge discoveries with its proprietary platforms, Retro Biosciences aims to develop novel, autologous blood stem cell therapies that could eliminate the fatal risks associated with donor mismatches and immunological rejection.

Endpoints News
May 15th, 2025
Retro Biosciences Seeks $1B Funding

Retro Biosciences, a longevity startup, has partnered with the Murdoch Children’s Research Institute in Australia to develop personalized blood disorder therapies. The company, backed by Sam Altman, is seeking $1 billion in funding.

Fortune
Jan 24th, 2025
Retro Biosciences Secures $1B for Longevity

Sam Altman is backing Retro Biosciences with a new funding round of $1 billion to extend human lifespan.