Full-Time

Chemistry – Manufacturing & Controls

CMC, Manager

Confirmed live in the last 24 hours

Absci

Absci

51-200 employees

Biotech company specializing in protein production

Biotechnology

Compensation Overview

$95k - $130kAnnually

+ Equity Package

Mid

Vancouver, WA, USA

Hybrid position requiring 50% onsite presence in Vancouver, WA.

Category
Computational Biology
Biology Lab & Research
Biology & Biotech
Required Skills
PowerPoint/Keynote/Slides
Requirements
  • Bachelor’s degree in a technical field such as chemistry, chemical engineering or pharmaceutical sciences. Advanced degree preferred. Specific project management training is desirable.
  • Minimum 3 years of industry experience in pharmaceutical development and manufacturing, with a focus on CMC; required knowledge of biologics development process; experience interacting with key functional stakeholders such as manufacturing, QA, QC, and supply chain.
  • Flexibility to work non-traditional work hours when needed, given international operations across time zones.
  • Proven experience of ability to prioritize, multi-task, and work in an evolving and high-pressure environment.
  • Proficiency in MS Office [Excel, Word, PowerPoint, MS Project], JMP statistical software (desired) and Adobe Acrobat.
  • Ability to create, and deliver presentations to influence and inform individuals across functions and levels within the organization.
  • Ability to travel up to 10% of the time. This will include outside of the United States.
Responsibilities
  • Function as technical lead at contract development and manufacturing organizations (CDMOs) for early phase biologics drug development for both Drug Substance and Drug Product, including tech transfer, scale up, gap/risk analysis, process characterization/qualification, cGMP manufacturing.
  • Provide technical guidance for cell line development, upstream process development, downstream process development, formulation development, analytical development, and drug product development.
  • Review and approve controlled documents including batch records, SOPs, protocols, and reports related to process development and characterization.
  • Preparation of program/platform dashboards and presentations.
  • Manage project budgets to target.
  • Responsible for assigned project/timeline planning and tracking of commitments, communication of commitments to team members.
  • Keep projects in compliance with cGMP regulations.
  • Coordinate activities to ensure efficient and cost-effective project completion.
  • Coordinate production of commercial batches as needed.
  • Ensure that senior management/development teams are informed of important program timelines, milestones and risks.
  • Work closely with QA/QC to identify and evaluate deviations, CAPA and change control.
  • Serve as a liaison between internal stakeholders and external partners, such as contract development and manufacturing organizations (CDMOs) and vendors.
  • Lead and direct the work of our partner organizations and consultants. Build strong communications and relationships with partner organizations and consultants.
  • Collaborate with CDMO for health authority inspection.
  • Adhere to all company policies, procedures and safety rules.

AbSci focuses on improving protein expression and biomanufacturing in the biotech industry. Its main product is an advanced protein expression platform that uses a semi-oxidizing cytoplasm and a dual inducible promoter system, allowing for better control over protein production rates. This results in higher quality and more efficient drug manufacturing. A key feature of AbSci's offerings is SoluPure, a method that simplifies protein purification without chromatography, speeding up the production process and reducing costs. AbSci's workflow can create cell lines that produce active proteins in as little as three months, which is much faster than traditional methods. Unlike its competitors, AbSci aims to replace older mammalian expression systems with its more efficient solutions. The company's goal is to enhance drug discovery and manufacturing processes for pharmaceutical and biotech companies, ultimately transforming the production of biologics.

Company Stage

IPO

Total Funding

$324.3M

Headquarters

Vancouver, Washington

Founded

2011

Growth & Insights
Headcount

6 month growth

3%

1 year growth

0%

2 year growth

-4%
Simplify Jobs

Simplify's Take

What believers are saying

  • AbSci's recent $86M public stock offering and strategic partnerships, such as with AstraZeneca, highlight strong financial backing and growth potential.
  • The company's ability to generate cell lines producing active protein products in as little as three months accelerates drug development timelines, offering significant time and cost savings.
  • AbSci's collaboration with PrecisionLife to develop an AI-enabled drug pipeline demonstrates their commitment to innovation and addressing unmet medical needs.

What critics are saying

  • The biotech industry is highly competitive, and AbSci must continuously innovate to maintain its edge over established and emerging competitors.
  • Relying heavily on strategic partnerships and collaborations could pose risks if these relationships falter or fail to deliver expected outcomes.

What makes Absci unique

  • AbSci's SoluPure technology offers a chromatography-free purification method, significantly reducing bottlenecks in protein production compared to traditional techniques.
  • Their advanced protein expression platform with a semi-oxidizing cytoplasm and dual inducible promoter system allows for precise control over protein production rates, setting them apart from competitors.
  • AbSci's integration of generative AI in drug discovery and biomanufacturing positions them uniquely in the biotech industry, combining cutting-edge technology with traditional biopharmaceutical processes.

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