Position Overview:

Beam is seeking a highly motivated Scientist/Senior Scientist to join our LNP Discovery group at our site in Cambridge, MA.

Primary Responsibilities:

• Design, synthesize, and characterize novel lipids, which will be used to formulate nanoparticles for encapsulation of base editor payloads.
• Discover and optimize new lipid components that drive the efficacy, selectivity, and safety of potential therapeutics.
• Help manage team of CRO chemists by providing synthesis targets, route troubleshooting, and feedback.
• Manage lipid inventory (physical stocks and electronic cataloging).
• Perform occasional bioconjugations linking lipid nanoparticles to auxiliary ligands.
• Work with other chemists, screening, and hit validation team members to facilitate smooth pipeline of testing novel lipid compositions.

Qualifications:

• Ph.D. in Chemistry (or related field) with 0-3 years industrial experience, or B.S./M.S. in Chemistry (or related field) with 5+ years industrial experience (job title commensurate with experience level).
• Documented track record of research focused in one of the following areas: organic chemistry, medicinal chemistry, or chemical biology.
• Skilled in multi-step organic synthesis and associated analytical techniques (column chromatography, mass spectrometry, NMR).
• Ability to analyze biological data and develop structure-activity relationships to guide design of new lipid analogs. Knowledge of cheminformatics and data analysis techniques a plus.
• Experience with lipid chemistry or bioconjugations could be advantageous, but is not required.
• An ideal candidate will demonstrate high levels of creativity, problem solving, and proficiency in organic synthesis.
• The ability to collaborate effectively throughout the company is also essential.