Principal Scientist @ Legend Biotech

Company Information

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell and natural killer (NK) cell-based immunotherapy.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel) in 2017. Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Legend Biotech is seeking Principal Scientist, Product Development as part of the US R&D team based in Piscataway, NJ.

Role Overview

Legend Biotechnology is seeking principal scientist to join our Product Development group and contribute to new technology/platform. This individual will report to the Executive Director in R&D. The successful candidate should possess extensive knowledge in oncology and immunology, in particular T and NK cell biology. The candidate will be able to lead the effort for developing in vivo cell therapy platform, building and optimizing cell-based immunoassays to characterize and assess immune cell functions. Experience with cell therapy, virus vector design and gene-editing is preferred. As co-lead of pipeline projects, the candidate needs to demonstrate the ability of delivering scientific results, and provide strategy, expertise, resources and guidance in a cross-functional environment.

Key Responsibilities

Develop T/NK cell therapy platform and optimize cell-based immunoassays, including vector design, virus packaging, T/NK cell isolation and expansion, multi-color flow cytometry, ELISA, cytotoxic assays. In vivo study design and assay development.
Design experiment to optimize process parameters, enhance cell engineering and manufacturing capacity
Independently design and execute experiments, document and interpret scientific results, present the data to cross-functional teams
Stay alert to industry development, good sense of new tech/platform in the field
Lead team to plan, execute, deliver and meet timeline
Help manage lab operation, keep good relationship with vendors

Requirements

PhD in cell biology/Immunology/virology, or master with extensive experience
10 years’ post-graduate experience in human immunology and oncology,>3 years of industry experience
Cell therapy, vector design, gene-editing

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Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

Legend Biotech maintains a drug-free workplace.

Key Responsibilities

Requirements

6 month growth

1 year growth

2 year growth