Full-Time

Principal Scientist Computational Chemist

Posted on 1/13/2025

MSD

MSD

Senior, Expert

No H1B Sponsorship

North Wales, PA, USA

This position requires in-person attendance at the West Point site.

Category
Bioinformatics
Computational Biology
Genomics
Biology & Biotech
Required Skills
Machine Learning

You match the following MSD's candidate preferences

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Degree
Experience
Requirements
  • Ph.D. or M.S. degree in chemistry, biochemistry, biophysics, or equivalent with a computational emphasis.
  • 8 years of relevant professional experience (i.e., Pharma, Biotech or equivalent) with a Ph.D., or 10 years with a M.S. degree.
  • Proficiency in general molecular modeling techniques (docking, molecular simulation, homology modeling, quantum mechanics, QSAR / machine learning, ligand- and structure-based design) with modern software packages (e.g. Schrodinger, OpenEye, CCG).
  • Evidence of creative application of computational approaches to solve problems of pharmaceutical interest.
  • Exceptional oral and written communication skills, with a recognized ability to positively and impactfully influence team decisions.
  • Ability to communicate, collaborate and deliver results in a fast-paced, global environment and to manage multiple priorities simultaneously.
  • Ability to see the ‘big picture’, and to identify opportunities for impact now and in the future.
  • Ability to lead strategic scientific initiatives relevant to drug discovery.
  • Passion for mentoring and coaching scientific peers.
Responsibilities
  • Design and optimization of drug candidates using advanced computational techniques as a member of discovery teams.
  • Functioning as a subject matter champion for ligand- and structure-based drug design across discovery teams.
  • Contributing to the continued growth and development of both modeling and chemistry colleagues as a mentor and influencer.
  • Advancing our modeling capabilities through invention and implementation of novel methodology as necessary to drive impact.
  • Mentorship and scientific development of M&I staff both locally and across our network.
  • Building fruitful collaborations with stakeholders across medicinal chemistry, pharmacokinetics & pharmacodynamics, quantitative biosciences, and therapeutic area biology.
  • Trusted partner for Discovery Chemistry in West Point.
  • Identifying computational chemistry needs and opportunities across two broad portfolios for neuroscience and infectious disease at our West Point Chemistry hub in Pennsylvania.
  • Leading specific strategic initiatives to enable our future vision for Modeling and Informatics in chemistry.
  • Enabling a design-driven and predict-first culture throughout our Company Chemistry.
  • Contributing to our Company’s overarching drug discovery strategy.
Desired Qualifications
  • Skilled in scientific programming (e.g. Python, Pipeline Pilot) and data analytics (e.g. Spotfire) and democratizing coding and workflows.
  • People management experience.

Company Size

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Company Stage

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Total Funding

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Headquarters

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Founded

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INACTIVE