Scientist I/II
Next Generation Sequencing
Posted on 9/18/2023
Chroma Medicine

51-200 employees

Cambridge, MA, USA
Experience Level
Medical, Clinical & Veterinary
Biology & Biotech
  • PhD. with 1-3 years or B.S./M.S. with 10+ years of relevant experience in developing and managing NGS assays and workflows with a degree in molecular biology, biochemistry, bioengineering, genetics, or related disciplines
  • Extensive experience in NGS assay development and implementation, such as methyl-seq, RNA-seq, amplicon sequencing, single-cell sequencing, etc
  • Hands-on experience with Illumina short-read sequencers
  • Proficiency in molecular biology techniques including DNA/RNA extraction, PCR, RT-qPCR, gel electriphoresis, fluorescence assays, etc
  • Team-oriented mindset with ability to work both independently and collaboratively
  • Passionate, adaptable, and keen on working in the fast-paced biotech startup space
  • Detail oriented and self-motivated, with excellent problem solving and organizational skills
  • Coordinate NGS production activities to fulfill sequencing needs to advance our epigenome editing platform
  • Optimize NGS production workflows and systems to streamline the production process by scaling up with automation, establishing SOPs, and communicating with other teams
  • Work both independently and as part of collaborative teams to execute assays that support development activities, project goals, and platform development, such as methyl-seq, RNA-seq, amplicon sequencing, etc
  • Troubleshoot NGS experiments to ensure assay robustness and generation of high-quality data
  • Work with the R&D team to transfer the developed tech and optimized process to production scale
  • Meet established timelines, maintain accurate records of work, and present data at team, departmental and company-wide meetings
Desired Qualifications
  • Experience operating an NGS production lab
  • Experience with PacBio or ONT long-read sequencers
  • Experience in the pharmaceutical or biotechnology industry
  • Experience leading project teams and working with external partners
  • Epigenetics, chromatin biology, gene editing, and/or transcriptional regulation knowledge a plus