Senior Director
Antibody Discovery
Posted on 3/26/2024
Voyager Therapeutics

51-200 employees

Develops gene therapies for neurological disorders
Company Overview
Voyager Therapeutics stands out in the biotechnology industry for its pioneering work in gene therapy and neurology, particularly in overcoming delivery challenges that have historically limited the potential of these disciplines. The company's TRACER AAV capsid discovery platform, which has generated novel capsids with high target delivery and blood-brain barrier penetration, is not only advancing Voyager's own pipeline of preclinical programs in Parkinson's disease, Alzheimer's disease, and ALS, but also fueling partnerships with industry leaders like Pfizer, Novartis, and Neurocrine Biosciences. Voyager's commitment to diversity and collaboration further enhances its competitive edge, fostering an inclusive culture that values different perspectives and is dedicated to making discoveries that can change the course of medicine for patients.
Biotechnology

Company Stage

N/A

Total Funding

$344M

Founded

2014

Headquarters

Cambridge, Massachusetts

Growth & Insights
Headcount

6 month growth

9%

1 year growth

41%

2 year growth

48%
Locations
Lexington, MA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
CategoriesNew
Computational Biology
Biology Lab & Research
Biology & Biotech
Requirements
  • PhD in chemistry, biochemistry, chemical biology, or a related field with 10+ years of industry experience
  • Demonstrated leadership and management experience with a track record of leading teams and projects to successful endpoints
  • Deep expertise in antibody/nanobody generation utilizing a wide range of technologies such as hybridoma, phage display, single B-cell screening, etc.
  • Demonstrated experience developing antibody bioconjugates, bispecific and multi-specific antibody formats for receptor-drive tissue targeting
  • Familiarity with performing developability/manufacturability assessments for selection and optimization of antibodies and antibody formats
  • Experience using bioinformatics tools for sequence and structure analysis
  • Proven leadership skills with mentoring and leading teams in therapeutic antibody development
  • Ability to work collaboratively in a high-paced project team environment, meet deadlines, and prioritize work across multiple projects
  • Strong written and verbal communication skills
  • Experience in CNS delivery strongly preferred
Responsibilities
  • Lead efforts in antibody/nanobody development and engineering, including bispecific, single domain, and multi-domain antibodies for non-viral CNS-penetrant therapeutic programs at Voyager Therapeutics
  • Utilize multiple strategies for antibody discovery such as hybridoma screening, B-cell screening, phage display to select and optimize top antibody candidates for affinity, transcytosis and other properties
  • Design and execute protein engineering strategies to deliver developable biologics formats by applying molecular biology, structure-guided, computational, combinatorial/display approaches
  • Lead and mentor an antibody engineering and molecular biology team of scientists responsible for designing, generating, and characterizing antibody-based therapeutics
  • Lead technology development in antibody engineering and contribute to broadening Voyager’s intellectual property portfolio
  • Hire, manage and develop a team of scientists/research associates fostering an environment of creativity, a strong work ethic and teamwork
  • Develop and manage operating budget