AbCellera is breaking the barriers of conventional drug development to propel antibody-based medicines from target to clinic. We are a team of scientists, engineers, creatives, and business professionals who believe that advancing science enhances lives. We have developed technologies to unlock high-value drug targets, including antibody-drug conjugates and T-cell engagers for cancer, and complex transmembrane proteins for indications such as metabolic and endocrine conditions, pain, and autoimmunity.

We are seeking a highly motivated Principal Scientist with a strong understanding of pharmacokinetics and bioanalytical methods for antibodies to join our multidisciplinary Pharmacokinetics (PK) team. In this role, you will help build our pharmacokinetics capabilities so we can move programs faster and with less risk to the clinic. You will be responsible for establishing the bioanalysis strategy across programs, supporting both discovery and development teams. 

How you might spend your days

• Leading efforts of establishing ligand-binding assays, cell-based methods, and LC-MS/MS methods to support the preclinical and clinical development of novel antibody therapeutics, including measurement of drug concentration, anti-drug antibodies, and neutralizing antibodies
• Identifying, selecting, and managing bioanalytical CROs for method optimization, assay transfer, qualification/validation, sample testing, and delivery of results within project timelines
• Generating bioanalytical study reports that adhere to global regulatory guidelines for IND/CTA/BLA/NDA filings
• Analyzing, interpreting, and presenting data to project teams and health authorities; supporting the preparation of regulatory documents for submission (e.g. summary documents and briefing packages)
• Representing the PK team on multiple cross-functional project teams
• Training and mentoring junior scientists

We’d love to hear from you if

• You are an expert in the design, development, and phase-appropriate qualification/validation of bioanalytical assay to support preclinical and clinical development of antibodies.  
• You have demonstrated expertise in authoring sections of regulatory submissions and are well-versed in scientific and regulatory standards for bioanalysis of biologics
• You are comfortable with non-compartmental data analysis (WinNonlin), and have a good understanding of PK parameters
• You have a PhD in Biology, Pharmacology, or related discipline with 10+ years of industry experience; candidates with a MSc and 12+ years of related industry experience will also be considered
• You are genuinely curious and energized by working with teammates  discussing innovative ideas in a highly collaborative and fast paced environment
• You excel in documentation and organizational skills and clearly  communicate scientific and technical concepts both verbally and in writing

What we offer:

AbCellera’s hiring range for this role is CAD $141,600 - $177,000 annually, commensurate with your education and job-related knowledge, skills, and experience. In addition to base salary, we offer equity, annual bonus dependent on team and company performance, and a 6% (non-match) RRSP contribution. 

You will have a CAD $1,500 annual Active Lifestyle Allowance, annual vacation, professional development opportunities, and comprehensive health benefits. Scientific and technical mentorship is a priority. And you’ll find we prioritize team building and connections across AbCellera.

About AbCellera:

AbCellera is a global company that discovers and develops antibody-based medicines that help people live longer, happier, and more productive lives. We are focused on bringing innovative medicines to patients, both by advancing our internal pipeline of programs and partnering with companies that have novel science or innovative technology.

And it all starts with our team. We’ve built a place where people feel they are part of something bigger than themselves. A place that exists to push the limits of science and technology, and aims to bring better therapies to patients.

We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success. 

To apply:

Please submit your application through our website and refer to Job ID 23212-D in your cover letter. We apologize in advance, but we receive a large volume of applications and are only able to contact those who are selected for an interview.

Workplace location: Vancouver, BC (preferred) or Montreal, QC 

Workplace arrangement: On-site

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