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Director – Delivery Chemistry
Confirmed live in the last 24 hours
Locations
Cambridge, MA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Requirements
  • PhD or MS in Organic / Medicinal or related field with 7 - 10 years of small molecule drug discovery experience
  • Dynamic energetic team leader who can build, mentor and develop high performing teams
  • Strong scientific background and publication record with proven high levels of performance
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change
Responsibilities
  • Provide leadership and strategic direction for delivery chemistry at Beam
  • Lead design and synthesis of novel chemical libraries to enhance delivery of nucleic acids in lipid nanoparticles
  • Effectively manage external chemistry resources to synthesize compounds
  • Engage with CDMOs to successfully scale lead compounds
  • Work closely with IP to develop small molecule patent strategy and lead preparation of patent documents
  • Work as part of project team to evaluate compounds and advance compounds through development
  • Collaborate closely with high throughput screening team, hit validation, non-clinical sciences and computational sciences to establish robust screening paradigm to inform SAR of chemical series
  • Communicate scientifically rigorous findings and delivery chemistry strategy via verbal and written communications, and presentations to key stakeholders (e.g. Executive leadership team, Board of Directors) and externally
  • Lead, teach and mentor junior staff to promote a culture of growth and learning
Desired Qualifications
  • Deep understanding of small molecule chemical synthesis, previous exposure to process chemistry is a plus
  • Prior experience in advancing novel chemical entities as part of multidisciplinary project team, familiarity with lipid excipients and lipid nanoparticles is a plus
  • Familiarity with delivery of oligonucleotides is a plus
Beam Therapeutics

501-1,000 employees