INACTIVE

Full-Time

Principal Scientist I/II

Mammoth Biosciences

51-200 employees

CRISPR disease detection biotech company

Food & Agriculture

Data & Analytics

AI & Machine Learning

Aerospace

Biotechnology

Compensation Overview

$118,750 - $215,250

Senior, Expert

San Bruno, CA, USA

Required Skills

Data Analysis

Requirements

Bachelor's degree in related field and 10+ years industry experience (or Master's degree and 8+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 6+ years of industry experience) (Principal Scientist I)
Bachelor's degree in related field and 12+ years industry experience (or Master's degree and 10+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 8+ years of industry experience) (Principal Scientist II)
Expertise in LNP formulation screening and optimization
Expertise in using design of experiment (DOE), relevant statistical softwares (JMP), and predictive analytics for formulation discovery

Responsibilities

Lead DOE-based LNP formulation screening/discovery campaigns directed toward in vivo and ex vivo delivery of Mammoth's proprietary CRISPR-based gene editing systems
Design, implement and execute early process development activities for LNP scale-up
Critically review and analyze data, and communicate results and conclusions; present and defend ideas in cross-functional meetings
Explore and evaluate non-viral delivery technologies for various therapeutics indications
Explore new orthogonal characterization assays and rigorously QC all the test articles
Manage the non-viral delivery projects to support deliverables along established timelines
Train, guide, and manage the researchers on various non-viral delivery activities

Desired Qualifications

Exposure to LNP scale-up and process development activities
Hands-on expertise in various basic analytical and biophysical methods/assays of LNP characterization such as, particularly size, zeta potential, and nucleic acid encapsulation/release, PKa, etc
Foundation in experimental documentation, basic statistical analysis and data presentation
Experience working with internal and external research collaborators and CROs
Highly motivated, hard working, and collaborative spirit

OPPORTUNITY

Mammoth Biosciences is hiring for a Principal Scientist I/II, Non-Viral Delivery. In this role the ideal candidate will be responsible for leading the lipid nanoparticle (LNP) formulation discovery and scale up activities for non-viral delivery technologies at Mammoth. The candidate will be responsible for the screening of various lipids and formulation/process parameters for the lead optimization for delivery of Mammoth’s proprietary CRISPR nucleases. In addition, will be responsible for in-house research-scale production, related process development, and quality control of the test articles to support Mammoth’s ex vivo and in vivo studies.

KEY RESPONSIBILITIES

Lead DOE-based LNP formulation screening/discovery campaigns directed toward in vivo and ex vivo delivery of Mammoth’s proprietary CRISPR-based gene editing systems
Design, implement and execute early process development activities for LNP scale-up
Critically review and analyze data, and communicate results and conclusions; present and defend ideas in cross-functional meetings
Explore and evaluate non-viral delivery technologies for various therapeutics indications
Explore new orthogonal characterization assays and rigorously QC all the test articles
Manage the non-viral delivery projects to support deliverables along established timelines
Train, guide, and manage the researchers on various non-viral delivery activities

REQUIRED QUALIFICATIONS

Bachelor’s degree in related field and 10+ years industry experience (or Master’s degree and 8+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 6+ years of industry experience) (Principal Scientist I)
Bachelor’s degree in related field and 12+ years industry experience (or Master’s degree and 10+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 8+ years of industry experience) (Principal Scientist II)
Expertise in LNP formulation screening and optimization
Expertise in using design of experiment (DOE), relevant statistical softwares (JMP), and predictive analytics for formulation discovery

PREFERRED QUALIFICATIONS

Exposure to LNP scale-up and process development activities
Hands-on expertise in various basic analytical and biophysical methods/assays of LNP characterization such as, particularly size, zeta potential, and nucleic acid encapsulation/release, PKa, etc.
Foundation in experimental documentation, basic statistical analysis and data presentation
Experience working with internal and external research collaborators and CROs
Highly motivated, hard working, and collaborative spirit

BENEFITS

Company-paid health/vision/dental benefits
Unlimited vacation and generous sick time
Company-sponsored meals and snacks
Wellness, caregiver, and ergonomics benefits
401(k) with company matching

Base Salary Range: $118,750 - $215,250

The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.

COMPANY

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth, and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.

Mammoth Biosciences

View

Website

View Company Profile

Mammoth is on a mission to develop technologies and products with passion and that can have a mammoth impact. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple condition.

Company Stage

Series D

Total Funding

$264.5M

Headquarters

Brisbane, California

Founded

2017

Growth & Insights

Headcount

6 month growth

↑ 0%

1 year growth

↑ 10%

2 year growth

↑ 18%

Benefits

Medical, dental, & vision

401(k)

Unlimited vacation

Transportation subsidy

Onsite amenities

Happy hours

INACTIVE