Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead is seeking a highly motivated Associate Scientist, Oligonucleotide Chemistry, to join our growing discovery chemistry team at our San Diego site. He/She will primarily focus on oligonucleotide synthesis, purification, and analysis. As an siRNA chemistry bioconjugation specialist, you will play a pivotal role in the development and optimization of siRNA-based therapeutics by leveraging your expertise in synthesis strategies and siRNA chemistry.
Responsibilities
- Operate oligo synthesizer to produce oligonucleotides with modified phosphoramidite
- Operate downstream processes for qualitative analysis and purification of novel chemically modified oligonucleotides
- Maintain a well-documented laboratory notebook
- Adhere to safe laboratory practice
- Perform tasks across different projects
- Manage time effectively to meet deadlines
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management
Requirements:
- B.S. or M.S. Chemistry degree with excellent understanding of organic and analytical chemistry
- Solid 3-8 years bench skills working in a chemistry laboratory
- Experience with a wide range of analytical techniques for oligonucleotides purification and analysis
- Ability to quickly learn new procedures and techniques
Preferred:
- Experience working with oligonucleotide purification in pharmaceutical setting
- Experience in Mermade synthesizer operation is a plus
California pay range
$80,000—$125,000 USD
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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