Responsibilities

• Purify enzyme and non-enzyme proteins, protein nanoparticles (AAVs, VLPs), and therapeutic nucleic acids (mRNA, circRNA) at small to medium scales to support strain engineering efforts at Ginkgo
• Develop protein/RNA/VLP purification methods at low, medium, and high throughput scale. 
• Develop diverse methods for continuous and discontinuous (quench-based) kinetics assays
• Translate kinetics and biophysical assays from traditional benchtop set ups to automated liquid handlers to develop higher throughput methodologies
• Perform electrophoresis, light-scattering, etc. to assess protein purity and biophysical characterization 
• Write Standard Operating Procedures (SOPs) and maintain a high-quality Electronic Laboratory Notebook (ELN)
• Prepare presentations and present data to internal and external Ginkgo partners
• Work with teams with diverse scientific backgrounds and varying biochemistry experience levels

Minimum Qualifications

• Bachelor’s degree (with 0 to 3 years of experience) or Master’s degree (0 to 1 year of experience) or equivalent in molecular biology, biochemistry, bioengineering, chemical engineering, biophysics, or related field.
• Understanding of molecular biology, recombinant protein expression and construct design for protein chromatography methods; familiarity with standard expression hosts such as mammalian, microbial, and yeast is a plus.
• Hands-on experience with protein and nucleic acid purification (affinity, IEX, MMC, HIC, SEC, etc.). Experience with AKTA FPLCs and method optimization is a plus.
• Hands on experience in biochemistry techniques such as protein expression, gel electrophoresis, protein quantification assays, and enzyme kinetics
• Interest in high-throughput methods for protein purification and characterization
• Enthusiasm to learn new techniques and strong curiosity of areas of biology previously unknown to you