Full-Time

Senior Enterprise Systems Analyst

Chan Zuckerberg Initiative

Chan Zuckerberg Initiative

501-1,000 employees

Philanthropic tech foundation funding science, education

Compensation Overview

$171k - $235k/yr

+ Annual performance bonus + Relocation support + 401(k) employer match

Redwood City, CA, USA

Hybrid

On-site at least 60% of the working month, approximately three days per week.

Category
IT Operations (1)
Required Skills
Claude
Agile
JavaScript
Git
Quality Assurance (QA)
Salesforce
JIRA
Confluence

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Requirements
  • At least 8 years of hands-on experience designing, developing, administering, and supporting large-scale Salesforce solutions, with deep expertise across Sales Cloud, Experience Cloud, and Service Cloud.
  • Salesforce Administrator Certification is required, with advanced proficiency in Salesforce Flow.
  • Proven experience managing complex technical programs, translating business needs into scalable solutions, and leading change management through training, enablement, and rollout communications.
  • Ability to translate organizational strategy into a clear platform vision and communicate effectively with technical and non-technical audiences.
  • Proficiency with Agile methodologies and tools such as Jira, Confluence, and Airtable.
  • Experience using artificial intelligence-powered tools such as ChatGPT, Claude, or Gemini to accelerate discovery and decision-making.
Responsibilities
  • Lead the planning, execution, and delivery of complex Salesforce platform initiatives across information technology, business units, and external partners.
  • Own and maintain the Salesforce platform roadmap, prioritizing competing business unit requests using structured frameworks.
  • Define and track platform success metrics, including adoption rates, user satisfaction, and cycle time, to demonstrate impact and guide roadmap decisions.
  • Communicate tradeoffs and priorities clearly to stakeholders at all levels.
  • Lead the design, configuration, and development of Salesforce solutions, translating business needs into technical specifications.
  • Perform hands-on configuration, testing, and quality assurance, resolve bugs, and support smooth release and deployment.
  • Leverage Agentforce and Einstein AI to automate workflows, surface insights, and improve the internal user experience.
  • Maintain technical documentation and drive continuous improvement based on feedback.
  • Serve as a trusted advisor and central point of contact across business, technical, and vendor stakeholders.
  • Gather requirements, define project goals, and secure alignment across teams and the technology roadmap.
  • Maintain a regular product communication cadence through release notes, feature announcements, and platform updates to drive awareness and adoption.
  • Provide ongoing updates and manage expectations at all organizational levels.
  • Stay current on Salesforce releases and emerging capabilities, including artificial intelligence, Agentforce, and Data Cloud, and incorporate relevant features into platform strategy.
  • Maintain Salesforce certifications and share new capabilities with the internal team.
  • Ensure solutions align with enterprise architecture and security standards while minimizing technical debt.
  • Partner with stakeholders to identify artificial intelligence automation opportunities and govern Agentforce agent deployment with security, legal, and leadership.
  • Identify risks and develop mitigation plans for Salesforce-related programs.
  • Ensure adherence to compliance, data security, and governance policies.
  • Manage vendor relationships and ensure service-level agreements are met.
Desired Qualifications
  • Experience with Agentforce, Einstein AI, Marketing Cloud, Data Cloud, CRM Analytics, user research, and artificial intelligence governance.
  • Experience with Conga Contracts, including Composer and Orchestrate; DocuSign integrations; Contract Lifecycle Management; Apex; Visualforce; JavaScript; GitHub; Gearset; Qualtrics; DocuSign Administration; or the philanthropy and grantmaking sector.
Chan Zuckerberg Initiative

Chan Zuckerberg Initiative

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The Chan Zuckerberg Initiative channels philanthropy and technology to speed progress in science, education, and community development by funding grants, making strategic investments, and building technology tools. It funds and builds practical tools such as personalized learning platforms and AI-assisted research tools, supports researchers, educators, and communities through grants and partnerships, and manages an endowment. It combines grant-making, investments, and technology development across education, science, and community work, emphasizes interdisciplinary collaboration, and uses AI to accelerate discovery while aligning tech with social goals. Its goal is to build a better future by expanding human potential and advancing equality through science, education, and community support.

Company Size

501-1,000

Company Stage

N/A

Total Funding

$2.9B

Headquarters

Menlo Park, California

Founded

2015

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Simplify Jobs

Simplify's Take

What believers are saying

  • June 2026 Rare As One expanded again, with patient-led grants and Every Cure partnerships.
  • October 2025 NVIDIA collaboration broadened access to open models, benchmarks, and petabyte-scale biology.
  • May 2025 Billion Cells Project advanced toward one-billion-cell datasets for training disease models.

What critics are saying

  • February 2026 layoffs cut 70 roles, exposing execution strain during the Biohub pivot.
  • If virtual cells fail to produce therapies by 2028, donor credibility and talent retention erode.
  • A concentrated science bet makes CZI existentially dependent on Zuckerberg’s continued willingness to fund billions.

What makes Chan Zuckerberg Initiative unique

  • Biohub links Zuckerberg capital, AI infrastructure, and wet-lab biology across elite universities.
  • CZI’s open virtual cells platform and CellxGene create unusually strong data moats.
  • The 2025 EvolutionaryScale acquisition added frontier AI talent directly into Biohub.

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Benefits

401(k) Company Match

401(k) Retirement Plan

Paid Vacation

Family Planning Benefits

Relocation Assistance

Mental Health Support

Wellness Program

Flexible Work Hours

Student Loan Assistance

Childcare Support

Company News

Fortune
Feb 1st, 2026
The Chan Zuckerberg Initiative cut 70 jobs as the Meta CEO's philanthropy goes all in on mission to 'cure or prevent all disease'

The Chan Zuckerberg Initiative cut 70 jobs as the Meta CEO's philanthropy goes all in on mission to 'cure or prevent all disease' The Chan Zuckerberg Initiative is making big changes, and it started 2026 with some job cuts to recalibrate and refocus its efforts on AI-powered biomedical research. The philanthropic organization, formed by Meta cofounder and CEO Mark Zuckerberg and his wife, Dr. Priscilla Chan, is cutting about 70 jobs, or roughly 8% of its workforce, a CZI spokesperson confirmed to Fortune. The layoffs happened primarily at the organization's Redwood City headquarters in San Mateo, Calif. In 2025, Zuckerberg and Chan laid the groundwork for remaking their philanthropic organization into one focused on AI-powered biomedical research, and its flagship Biohub network in particular. Their move extends a broader retreat from the couple's earlier push into education and social-justice causes, although they'll continue to make donations to local organizations. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done," Zuckerberg said during an event at the Biohub Imaging Institute in Redwood City in November, according to the Associated Press. "So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward." The couple has dedicated, through the Giving Pledge, to give away 99% of their lifetime wealth. Their massive move also underscores how big donors are racing to back science-heavy, tech-centric projects such as peers like the Gates Foundation. The philanthropy started by Bill and Melinda French Gates will shutter in 2045 and has plans to make a record $9 billion in donations this year while remaining primarily focused on health care and disease research. Why CZI had layoffs and its pivot to Biohub. Because the Chan Zuckerberg Initiative has big plans to expand its biomedical and science focus and step a little further back from its original focus areas of education, criminal justice reform, housing, and community development, it now needs employees with expertise in their new coverage areas. While some were able to be assigned to other teams, the organization needed more research-heavy expertise to match the new mission, so some had to be laid off. They received a 60-day notice period and will get a severance package with 16 weeks of base pay, health insurance, and a $10,000 stipend to help with other needs. The layoffs came as part of a decision to concentrate resources on Biohub, a growing network of biomedical research institutes that aims to "cure or prevent all disease," according to Zuckerberg and Chan. It currently operates as a collaborative network of nonprofit research centers, partnering with universities like UC San Francisco, Stanford, UC Berkeley, Northwestern, and Columbia. Biohub is focused on advancing biomedical science, engineering, and artificial intelligence to cure, prevent, or manage all diseases. CZI will continue to hire and grow its team, but with more science-focused roles like researchers, data scientists, computational biologists, and more. Since Biohub's 2016 inception, the couple has donated $4 billion to basic science research, and is on track to double that amount during the next decade, according to the AP. The organization has an operating budget of about $1 billion per year. "We will continue our other philanthropic efforts as well, but the Chan Zuckerberg Initiative will serve as infrastructure and support for our initiatives," the couple wrote in a blog post in November. "There will be many challenges, but we believe that achieving some of humanity's long-term dreams will also come within reach." CZI's shared AI obsession with Meta. Like Zuckerberg's $1.81 trillion tech company Meta, CZI is going all-in on AI-focused research and outcomes. Both his business and philanthropic efforts are now squarely focused on AI, with Meta committed to spending between $115 billion and $135 billion on building "superintelligent" agents for user needs across feeds, ads, and commerce. CZI's Biohub similarly is focused on "frontier AI" and "frontier biology," using large-scale models for virtual cells, immune reprogramming, and disease prediction. With those efforts, Zuckerberg has framed 2026 as AI's transformative year for work at both Meta and CZI. "Accelerating science is the most positive impact we think we can make," Zuckerberg and Chan wrote in the November blog post. "So we're going all in on AI-powered biology for our next chapter."

GenomeWeb
Nov 7th, 2025
CZI Acquires EvolutionaryScale for Biohub

The Chan Zuckerberg Initiative (CZI) has acquired EvolutionaryScale, a company focused on AI algorithms for life sciences, as part of a restructuring to form Biohub, a new entity combining CZI Science and Chan Zuckerberg Biohub network. This will be the main philanthropic focus for Mark Zuckerberg and Priscilla Chan. EvolutionaryScale Cofounder Alex Rives will lead science at Biohub. Financial details of the acquisition were not disclosed.

RamaOnHealthcare
Jul 24th, 2025
Chan Zuckerberg Initiative Introduces New GREmLN Model For Genetics

Chan Zuckerberg Initiative introduces new GREmLN model for genetics.

Forbes
May 13th, 2025
Somite AI Raises $47M for Cell Therapy

Somite AI has raised $47 million in a Series A funding round, led by Khosla Ventures, bringing its total funding to about $60 million. The startup aims to revolutionize cell replacement therapy using its AI platform, DeltaStem, to produce any human cell type. This approach could address diseases like Type 1 Diabetes and muscular disorders. Somite's method involves using semi-permeable capsules to efficiently generate data, enhancing the development of AI models for stem cell biology.

PR Newswire
May 5th, 2025
Psomagen Selected As Key Service Provider, Will Utilize Ultima Genomics' Ug 100™ Sequencer To Accelerate Chan Zuckerberg Initiative'S Billion Cells Project

ROCKVILLE, Md., May 5, 2025 /PRNewswire/ -- Psomagen Inc., a multiomics service laboratory serving academic, pharma, biotech, and clinical customers, will join the Billion Cells Project led by the Chan Zuckerberg Initiative (CZI). The Billion Cells Project aims to develop a landmark single-cell dataset of one billion cells that will be used to train new AI models to advance researchers' understanding of cellular behavior and gene function. Psomagen has begun providing services to participating researchers in April. The project includes collaborations with several other technology partners, including Ultima Genomics, 10x Genomics and Scale Biosciences. Su Hong, CEO of Psomagen, says, "This project represents a transformative step in biomedical research, enabling the identification of novel therapeutic targets and guiding drug development with unparalleled precision. By leveraging AI-powered analysis on vast single-cell datasets, we aim to accelerate the discovery of new ways to restore diseased cells to health