Position Overview:

Beam is seeking a motivated and collaborative individual to join our Protein Sciences group responsible for supporting method development, purification, and characterization of our novel base editors and other proteins of interest. The successful applicant will have experience in molecular biology, protein expression systems (bacterial/mammalian/yeast), and protein chromatography. Candidates should be highly self-motivated with an analytical mindset with the ability to excel in a fast-moving and goal-oriented environment.

Responsibilities:

• Contribute to the scientific strategy, discussion, and output of the team.
• Perform and evaluate studies to improve yield and purity of purified targets.
• Perform protein expression and purification of novel base editors and proteins of interest.
• Assist in method development campaigns to assess robustness of purification strategies.
• Assist in the design and implementation of activity and release criteria assays of purified base editors/target proteins.
• Assess scientific literature and properly apply it to increase knowledge base.
• Document, present, and communicate scientific findings.

Qualifications:

• BS in Chemistry, Biochemistry, Chemical Biology, Molecular Biology, Biotechnology, Chemical Engineering or equivalent and a minimum of 1 year (RA) to 4 years (Sr. RA) of experience in protein biochemistry.
• Familiarity operating AKTA FPLC instruments.
• Theoretical and practical knowledge on purification sciences with an emphasis on strategies applied to the purification of biological macromolecules.
• Proficient in molecular biology applications including primer design cloning, DNA purification and quantification methods.
• Candidate must be familiar running various protein characterization assays (SDS-PAGE, UV-VIS spectroscopy).
• Self-driven, analytical, and detail-oriented scientist with a strong problem-solving mindset and a strong curiosity towards areas of protein science previously unknown to you.
• Excellent written and verbal communication skills with the ability to present effectively to teams with diverse scientific backgrounds.
• Familiarity with the use of ELNs and inventory management.
• Familiarity with DoE approaches for the improvement of purification processes.
• Familiarity with plasmid mechanics (g. selection of RBS strength, promoter strength, protein induction strategies).
• Familiar with the use of programs like MS Excel, MS PowerPoint, GraphPad Prism, Geneious, and JMP.