Full-Time
Biopharma developing kinase inhibitors for cancer
$190k - $240k/yr
Cambridge, MA, USA
In Person
Up to 25% travel within the United States.
Bachelor's, MBA
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Blueprint Medicines develops and commercializes kinase inhibitors for cancer and other diseases. Its lead product, Ayvakit (avapritinib), blocks enzymes that drive tumor growth in gastrointestinal stromal tumors with PDGFRA exon 18 mutations. The company also has a pipeline of other kinase inhibitors in clinical development for lung, breast, and blood cancers, plus preclinical programs in immunology and rare diseases. By performing discovery, development, and commercialization in-house, it aims to bring targeted therapies to patients with unmet medical needs and expand its global oncology portfolio.
Company Size
501-1,000
Company Stage
IPO
Headquarters
Cambridge, Massachusetts
Founded
2011
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Health Insurance
Dental Insurance
Vision Insurance
401(k) Retirement Plan
401(k) Company Match
Unlimited Paid Time Off
Commuter Benefits
Mental Health Support
Employee Stock Purchase Plan
Parental Leave
Sanofi to lay off 229 Blueprint employees, close offices. Sanofi is laying off 229 former Blueprint Medicines employees in Cambridge, MA and closing two legacy Blueprint facilities. The news comes just over a year after Sanofi's $9 billion acquisition of Blueprint, one of the biggest deals of 2025. Boston Business Journal broke the news, which pharmaphorum has independently verified with the company. "As part of the integration following our acquisition of Blueprint Medicines in July 2025, we made thoughtful organisational decisions to align our structure with our long-term business priorities and the needs of our commercial portfolio and pipeline," Sanofi said in an emailed statement. "These decisions were made carefully to position the organisation for future success while continuing to deliver for patients. Many Blueprint employees are joining Sanofi. Those affected by these decisions have already been informed and we will continue to provide multiple avenues of support through their transitions." Blueprint's facilities at 45 Sidney St and 38 Sidney St in Cambridge are closing, with remaining Blueprint employees reporting to Sanofi's East Cambridge office. Since the acquisition was finalised in July 2025, there's already been an exodus of Blueprint talent at the top levels of the company. All 13 members of Blueprint's leadership team (as listed on their website at the time) have left the company in the last year, with most departing in October of last year, according to LinkedIn. Chief scientific officer Percy Carter has been leading preclinical and translational sciences at Pfizer, chief commercial officer Philina Lee is now CEO at AdvanceCell, R&D president Fouad Namouni is CEO at Synolo Therapeutics, and three separate members of the team - chief medical officer Dr Becker Hewes, chief business officer Sherwin Sattarzadeh, and SVP corporate affairs Jim Baker - have landed in similar roles at Damora Therapeutics, a Boston biotech focused on blood disorders. Sanofi acquired Blueprint to secure the rights to Ayvakit/Ayvakyt (avapritinib), a tyrosine kinase inhibitor (TKI) that targets the KIT D816V mutation in ASM, an umbrella term that covers multiple disorders, including aggressive systemic mastocytosis, systemic mastocytosis with an associated haematological neoplasm (SM-AHN), and mast cell leukaemia (MCL). Ayvakit is the only approved medicine for ASM, which causes symptoms like itching, fever, abdominal pain, and nausea, and can also lead to organ damage, bone fractures, and anaemia. People with ASM typically have a life expectancy ranging from six months to around three-and-a-half years. According to recent Sanofi financial reports, Aykavit earned the company €367 million in net sales in the first half of 2026. 17 August, 2026
Sanofi has acquired the American biotech company Blueprint Medicines, which specializes in systemic mastocytosis, a rare disease characterized by abnormal activation or proliferation of mast cells in tissues, most commonly the skin and bone marrow.
Sanofi is set to acquire Blueprint Medicines for an equity value of $9.1 billion, according to Bloomberg.
Sanofi is acquiring Blueprint Medicines for approximately $9.1 billion, enhancing its immunology portfolio. This acquisition includes Ayvakit, the only FDA-approved treatment for systemic mastocytosis, and promising therapies like elenestinib and BLU-808. Sanofi will finance the deal with cash and new debt, expecting it to boost gross margin and operating income post-2026. The merger aligns with Sanofi's strategy to lead in immunology and address rare diseases.
PARIS (Reuters) -France's Sanofi has agreed to buy U.S.-based Blueprint Medicines Corporation for up to $9.5 billion to boost its position in rare immunology diseases, in the biggest deal struck by a European healthcare company so far this year, according to LSEG data.