Scientist Structural Biology

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Job Description

We are seeking a highly skilled and motivated PhD level Structural Biologist with expertise in protein crystallography. A strong candidate will possess a strong background in the field of structural biology and will use this expertise to generate data, interpret structures and provide valuable insights to advance Takeda’s drug discovery programs. A successful candidate will work with internal and external teams to execute structure-based efforts and protein production requirements as well as collaborate with cross-functional teams to progress Takeda’s pipeline.

The successful candidate will:

• Plan and execute gene-to-structure projects and generate target co-complex structures with small molecules and/or biologic proteins using in-house crystallization capabilities and contract research organizations
• Analyze proprietary and public structural information to positively impact computational and medicinal chemistry efforts and/or antibody design, optimization and characterization
• Work collaboratively on pipeline projects with an interdisciplinary team (biologists, medicinal and computational chemists, in vitro and in vivo pharmacologists, informatics scientists, DMPK, project management)
• Utilize, support and build upon the capabilities of in-house hardware, software and database resources and engage productively with external structural biology and protein chemistry contract research organizations to achieve project and department goals
• Clearly communicate structural data, interpretation and insights to diverse audiences including structural biology group, project teams, department colleagues and senior leadership.

A sucessful candidate should have:

• PhD degree in Structural Biology, Biophysics, Biochemistry/Enzymology, Protein Chemistry or a related field with 3+ years industry experience in pharmaceutical or biotechnology structural biology role; MS with 8+ years or BS with 12+ years industry experience also considered
• Demonstrated track record of supporting high-quality structure determination and validation of protein co-complexes to rapidly advance drug discovery pipelines
• Experience utilizing crystallographic and modeling software package including, but not limited to, CCP4, HKL2000/3000, PHENIX, COOT, Schrodinger software, PSILO
• Extensive knowledge of and experience in protein production including construct design/protein engineering, protein expression systems (bacterial, insect, mammalian systems), protein purification techniques and protein characterization methods
• Experience with cryo-EM methods and structure determination, biophysical techniques (SPR, ITC, DLS, etc), crystallization automation capabilities, membrane protein production and characterization and/or CRO management is highly desirable
• Passion for learning and advancing structural biology capabilities and drug discovery pipelines, including proactive investigation of new techniques and capabilities, advanced software and hardware and innovative experimental approaches Ability to work collaboratively in a fast-paced, matrixed environment with a collaborative and proactive mindset, motivated by a desire to create therapeutic molecules for the benefit of patients in need worldwide

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$108,500.00 - $170,500.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

YesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.