Sr. Scientist
Conjugation Development
Posted on 3/22/2024
INACTIVE
Vaxcyte

201-500 employees

Develops broad-spectrum vaccines for bacterial diseases
Company Overview
Vaxcyte is a pioneering vaccine company that is redefining the production of complex immunizations through advanced synthetic techniques, including the XpressCFᵀᴹ cell-free protein synthesis platform, which is designed to expedite the creation and delivery of high-fidelity vaccines. The company's lead candidate, VAX-24, a broad-spectrum pneumococcal conjugate vaccine, has been granted FDA Breakthrough Therapy designation, demonstrating its potential in preventing invasive pneumococcal disease. With a culture focused on eradicating or treating invasive bacterial infections, Vaxcyte is leading the industry in developing vaccines with an expanded breadth of coverage, including candidates designed to prevent Group A Strep infections and slow the progression of periodontal disease.
Biotechnology

Company Stage

N/A

Total Funding

$2.3B

Founded

2013

Headquarters

San Carlos, California

Growth & Insights
Headcount

6 month growth

26%

1 year growth

65%

2 year growth

161%
Locations
San Carlos, CA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
CategoriesNew
Lab & Research
Life Sciences
Physical Sciences
Requirements
  • PhD in Chemistry, Biochemistry, or related field with 5+ years of industry experience, MS with 8+ years, or BS with 10+ years of experience.
  • Strong biochemistry and organic chemistry knowledge base underpinning several years' experience preparing bioconjugates.
  • Subject matter expertise with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration.
  • Subject matter expertise with techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS.
  • Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods.
  • Experience with Design of Experiments is desirable.
  • Experience with chemical modification of polysaccharides is desirable.
  • Experience implementing and/or using electronic notebooks is desirable.
Responsibilities
  • Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates.
  • Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
  • Analyze polysaccharides and conjugates with a variety of analytical methods.
  • Advise team members on experimental design, interpretation of results, and troubleshooting.
  • Model and train team members on best practices for adherence to protocols and data management.
  • Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations.
  • Maintain highly organized records to enable optimization and assessment of reproducibility.
  • Attend team meetings ready to provide updates on conjugation development progress.