Full-Time

Staff Network Engineer

Updated on 5/26/2026

GRAIL

GRAIL

1,001-5,000 employees

Blood-based cancer detection via sequencing tests

Compensation Overview

$135k - $179k/yr

+ Bonus + Incentives

Menlo Park, CA, USA + 1 more

More locations: Sunnyvale, CA, USA

Hybrid

Hybrid role; minimum 80% on-site; moving to Sunnyvale, CA in Fall 2026.

Category
DevOps & Infrastructure (1)
Required Skills
Juniper
CloudFormation
AWS
Terraform
Observability
Route 53
Requirements
  • 10+ years of experience in network engineering, with at least several years in a senior/staff or architecture-oriented role.
  • Deep, hands-on experience with AWS networking: Amazon VPC (CIDR design, subnets, IGW/NAT, route tables, endpoints); Security Groups and NACLs; AWS Transit Gateway, Site-to-Site VPN, and AWS Direct Connect; Route 53 and ELB (ALB/NLB/GLB).
  • Strong enterprise/data center networking experience: Juniper and/or Aruba networking platforms; Routing/switching (BGP, OSPF, VLANs, VRFs, link aggregation, redundancy protocols).
  • Hands-on experience with Palo Alto Networks firewalls; Demonstrated experience setting up monitoring, logging, and dashboards; Proven track record building and operating secure, highly available, and scalable network infrastructures in production.
  • Solid understanding of network security principles, segmentation, and zero-trust concepts.
  • Strong troubleshooting skills across layers (DNS, TCP/IP, TLS, HTTP, internal app protocols).
  • Infrastructure as Code: Hands-on experience using Terraform or CloudFormation; comfortable owning both architecture and automation.
  • Excellent communication skills and experience working in cross-functional, fast-moving environments.
Responsibilities
  • Staff Network Engineering - AWS and Hybrid Cloud
  • Design, build, and maintain Amazon VPCs including CIDR planning, subnet design (public/private), route tables, Internet Gateways (IGW), NAT gateways, and VPC endpoints (Interface/Gateway).
  • Configure and manage security controls such as Security Groups, Network Access Control Lists, AWS Network Firewall, and AWS Web Application Firewall for defense‑in‑depth across environments.
  • Implement and support hybrid connectivity using AWS Direct Connect, Site‑to‑Site VPNs, and AWS Transit Gateway for scalable VPC‑to‑VPC and on‑prem connectivity.
  • Configure Amazon Route 53 for internal and external DNS, routing policies, health checks, and failover.
  • Deploy and manage Elastic Load Balancing (ALB/NLB/GLB) to provide high availability, SSL termination, path‑based routing, and/or TCP/UDP load balancing.
  • Operate and troubleshoot on‑prem and data center networks using Juniper and Aruba platforms (switching, routing, VLANs, VRFs, BGP/OSPF).
  • Configure, manage, and tune Palo Alto Networks firewalls, including security policies, NAT, VPN, and content inspection.
  • Design and implement end‑to‑end monitoring, alerting, and dashboards for network health, performance, and security, leveraging tools such as: VPC Flow Logs, CloudWatch metrics/logs, and Route 53 health checks; Firewall logs and on‑prem device telemetry.
  • Build and maintain dashboards for: Link utilization, latency, packet loss, and error rates (DX, VPN, TGW, campus links); Load balancer health, connection metrics, and capacity; DNS performance and resolution issues.
  • Establish actionable alerting thresholds and runbooks to support rapid incident triage and resolution.
  • Perform ongoing capacity planning for AWS networking (VPCs, TGW, DX, VPN, load balancers) and on‑prem links, forecasting growth and identifying bottlenecks.
  • Analyze traffic patterns and utilization data to right‑size connectivity, optimize routing, and plan upgrades before they become constraints.
  • Run performance tests and baselines (throughput, latency, failover behavior) and tune configurations accordingly.
  • Lead network‑related incident response, including real‑time troubleshooting across layers (DNS, TCP/IP, TLS, HTTP, internal app protocols).
  • Drive root‑cause analysis (RCA) and implement corrective and preventive actions (runbooks, automation, design changes).
  • Own end‑to‑end network architecture for multi‑account, multi‑region AWS environments, ensuring scalability, reliability, observability, and security.
  • Develop and maintain network reference architectures and patterns for: Isolated and regulated environments; Service‑to‑service connectivity using PrivateLink, VPC peering, and/or VPC Lattice; Ingress/egress patterns through ELB, Global Accelerator, and centralized egress VPCs; Design application connectivity, segmentation, and zero‑trust network patterns in partnership with Security and Platform teams; Evaluate and introduce advanced AWS networking capabilities (e.g., AWS App Mesh, Amazon VPC Lattice, AWS Global Accelerator) where they provide clear operational or performance benefits; Ensure architectural designs explicitly include observability and capacity planning requirements (telemetry, KPIs, SLOs).
  • Build and maintain infrastructure‑as‑code for network components (Terraform/CloudFormation modules for VPCs, TGWs, Direct Connect, routing, firewall rules).
  • Integrate network provisioning and configuration into CI/CD pipelines to support safe, auditable, and repeatable deployments.
  • Automate generation and updates of network monitoring, logging, and dashboard configurations where possible.
  • Define and codify network standards, guardrails, and best practices for AWS and on‑prem networking, including monitoring and capacity baselines.
  • Partner with Security and Compliance to ensure designs and implementations meet regulatory and internal policy requirements, including logging and retention requirements.
  • Act as the primary subject matter expert for AWS networking, hybrid connectivity, and network observability, providing guidance to platform, SRE, security, and application teams.
  • Mentor other engineers on networking fundamentals, AWS networking, performance troubleshooting, and effective monitoring/dashboards.
  • Lead and review technical designs, RFCs, and architectural decisions for network‑related projects.
  • Communicate complex networking concepts, trade‑offs, and capacity risks to both technical and non‑technical stakeholders.
Desired Qualifications
  • Experience in healthcare, life sciences, or other highly regulated or security‑sensitive environments.
  • Experience with AWS Network Firewall, AWS WAF.
  • Experience with AWS App Mesh and/or Amazon VPC Lattice.
  • Experience with AWS Global Accelerator and edge networking patterns.
  • Proficiency with infrastructure‑as‑code (Terraform, CloudFormation) and automation/scripting (Python, Bash, PowerShell).
  • Experience designing SLOs, KPIs, and alerting strategies for network reliability and performance.
  • Familiarity with SD‑WAN, SASE, and/or Zero Trust Network Access solutions.
  • Relevant certifications such as AWS Certified Advanced Networking – Specialty, CCNP/CCIE, or Palo Alto Networks certifications.

GRAIL develops blood-based cancer tests that aim to detect cancer at its earliest stages. The tests use high-intensity sequencing to analyze large amounts of tumor genome data from a blood sample and apply advanced algorithms and deep learning to identify signals indicating cancer. Revenue comes from selling these tests to healthcare providers and research institutions, with potential expansion to direct-to-consumer sales in the future. Compared with others, GRAIL combines extensive sequencing data with clinical studies and sophisticated analytics to provide actionable cancer-detection results, focusing on early diagnosis. The company’s goal is to lower global cancer mortality by catching the disease early when treatment is more effective.

Company Size

1,001-5,000

Company Stage

Post IPO Equity

Headquarters

Menlo Park, California

Founded

2016

Simplify Jobs

Simplify's Take

What believers are saying

  • Epic integration should reduce ordering friction inside large health systems.[360dx, 2026]
  • Q1 2026 test volume grew 50%, showing strong provider demand.[360dx, 2026]
  • FDA PMA review and ASCO 2026 data are near-term catalysts.[360dx, 2026]

What critics are saying

  • NHS-Galleri missed its primary endpoint, weakening population-level utility claims.[recent news articles, February 2026]
  • Galleri remains unapproved by FDA, limiting broad U.S. commercialization.[1][3]
  • The $949 list price restricts adoption outside affluent, high-risk patients.[9]

What makes GRAIL unique

  • Galleri is GRAIL’s flagship MCED blood test for 50+ cancer types.[2][7]
  • GRAIL combines methylation sequencing, machine learning, and cancer signal origin prediction.[2]
  • CLIA and CAP laboratory certification supports prescription-only adoption before FDA approval.[6][7]

Help us improve and share your feedback! Did you find this helpful?

Your Connections

People at GRAIL who can refer or advise you

Benefits

Outstanding People - Join a team of passionate and dedicated professionals, committed to collaboration, education, and proactive problem-solving.

Strong Compensation - We offer competitive salaries and savings plans to provide for long-term financial planning.

Complete Health Coverage - Take advantage of comprehensive health coverage, with medical, dental and vision, to keep you and your family healthy.

Work-Life Balance - Make everyday life more manageable with flexible time off – we trust you to do great work and take time for yourself.

Growth & Insights and Company News

Headcount

6 month growth

-1%

1 year growth

-1%

2 year growth

0%
Clinical Lab Products
May 7th, 2026
GRAIL to present new data on multi-cancer early detection test.

GRAIL to present new data on multi-cancer early detection test. Presentations will feature results from the NHS-Galleri and PATHFINDER 2 studies involving more than 174,000 participants. GRAIL will present additional data from the NHS-Galleri trial and the PATHFINDER 2 study at the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting. The presentations will further evaluate the Galleri multi-cancer early detection (MCED) test during the event held May 29 to June 2, 2026, in Chicago. The NHS-Galleri trial presentation will expand on topline results announced in February 2026. As a randomized controlled study of an MCED test, it was designed to demonstrate population-level impact through the reduction of late-stage cancer diagnosis and increased cancer detection rates within the National Health Service (NHS) in England. The trial evaluated annual screening with the Galleri test in addition to standard of care screening over three years in more than 142,000 participants aged 50 to 77. The complete dataset from the PATHFINDER 2 study, which includes more than 32,000 evaluable participants, will also be presented. Conducted under a Food and Drug Administration (FDA)-approved investigational device exemption, PATHFINDER 2 is an MCED interventional study in North America focused on an intended-use population with no clinical suspicion of cancer. "These results from NHS-Galleri and PATHFINDER 2, two large, rigorous studies, underscore Galleri's strong performance, ability to shift detection of cancers earlier before metastatic disease, and strong safety profile," says Josh Ofman, president of GRAIL, in a release. "We look forward to sharing these findings, which strengthen the body of evidence supporting the clinical utility, performance, and safety of Galleri in intended-use populations and reflect GRAIL's extensive experience building a robust evidence base for multi-cancer early detection." Additional data will include a poster presentation on the implementation of the MCED test in private practice settings. This study examines adoption, performance, and repeat-testing patterns for the blood-based screening tool. The GRAIL clinical laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and accredited by the College of American Pathologists. While the Galleri test is intended for clinical purposes, it has not been cleared or approved by the FDA. The test is currently recommended for adults with an elevated risk for cancer, such as those aged 50 or older, and is intended to be used in addition to routine cancer screening tests. Photo caption: Galleri test Photo credit: File/GRAIL Related Reading:

PR Newswire
Apr 10th, 2026
Junction partners with GRAIL to enable multi-cancer screening through diagnostic platform

Junction, a diagnostic testing infrastructure platform, has announced a collaboration with GRAIL to support access to the Galleri multi-cancer early detection test across digital health platforms and clinical organisations. Through Junction's infrastructure, healthcare providers can integrate Galleri into their workflows with unified ordering, embedded physician networks and streamlined operational support. The Galleri test is a blood test designed to detect signals from over 50 cancer types, many lacking recommended screening options. Junction's platform enables organisations to order the Galleri test directly, support multi-state clinical operations and manage complex testing workflows. The collaboration aims to simplify the operational steps around offering Galleri, making it easier for providers to integrate the test into care delivery. Junction provides infrastructure that powers healthcare platforms through a single API.

360Dx
Apr 7th, 2026
Grail, Epic partner to broaden Galleri MCED test ordering.

Grail, Epic partner to broaden Galleri MCED test ordering. NEW YORK - Grail on Tuesday announced a collaboration with Epic to integrate the Galleri multi-cancer early detection test into Epic's electronic health record platforms. Get the full story with 360dx Premium. Only $95 for the first 90 days. Full site access Interest-based email alerts Premium Access - Trial Offer $95.00 for 3 month

Yahoo Finance
Mar 22nd, 2026
One Fin exits $22M GRAIL stake before 50% crash

One Fin Capital Management completely exited its position in GRAIL on 17 February 2026, selling approximately 380,000 shares worth $22.47 million. The timing proved fortuitous, as GRAIL subsequently experienced a roughly 50% single-day decline following an earnings announcement. The liquidation reduced GRAIL's weighting in the fund's portfolio from 7.4% to zero. GRAIL, a biotechnology company specialising in blood-based multi-cancer early detection, had been a strong performer with shares up 68% year-to-date prior to the crash. Despite selling over 185,000 Galleri tests and generating $147.2 million in revenue, GRAIL reported a net loss of $408.35 million. The company's current market capitalisation stands at $1.9 billion.

Clinical Research News
Mar 19th, 2026
ClearNote Health appoints Jeffrey Venstrom, MD, as chief medical officer and expands leadership team to drive clinical adoption of early cancer detection tests.

ClearNote Health appoints Jeffrey Venstrom, MD, as chief medical officer and expands leadership team to drive clinical adoption of early cancer detection tests. Mar 19, 2026, 07:46 AM by The team at ClearNote Health strengthened its leadership team with four key additions. Daniel Black named general manager of international markets; Irene Hsieh named vice president of regulatory affairs and quality assurance; Jeremy Bennett named head of marketing SAN DIEGO - March 18, 2026 - ClearNote Health, a company focused on improving early detection for some of the deadliest cancers, today announced four strategic additions to its executive leadership team: Jeffrey Venstrom, MD, as chief medical officer; Daniel Black, DBA, as general manager of international markets; Irene Hsieh as vice president of regulatory affairs and quality assurance; and Jeremy Bennett as head of marketing. These appointments mark a significant milestone as the company expands clinical validation, advances regulatory pathways, and drives broader global commercial adoption of its proprietary early cancer detection tests and epigenomic drug development platform. "We're building a leadership team with the experience and vision required to transform early cancer detection at a global scale," said Dave Mullarkey, CEO of ClearNote Health. "Jeff, Daniel, Irene, and Jeremy bring a proven track record of scaling innovative healthcare organizations and translating breakthrough science into real-world clinical impact. Their leadership will help accelerate adoption of our technology, expand our clinical reach, and give more patients the opportunity to detect cancer earlier, when treatment options and outcomes are greatest." Strengthening Clinical Leadership As chief medical officer, Dr. Venstrom will lead clinical development, medical affairs, and real-world evidence generation for early cancer detection. A physician-scientist with deep expertise in oncology, hematology, and drug and diagnostic development, he brings decades of leadership across academic medicine and global biopharma. Prior to joining ClearNote Health, Dr. Venstrom served as the global head of diagnostics for Eli Lilly and Company and the chief medical officer at Grail. Prior to that, he spent eight years at Roche / Genentech, including two years as head of clinical development and medical affairs at Foundation Medicine. Earlier in his career, he held the Krishnamurthi Endowed Chair in Hematologic Malignancies at the University of California, San Francisco, where he provided clinical care for cancer patients and served as principal investigator for several industry-sponsored translational research trials and collaborations. Dr. Venstrom completed his clinical oncology and cancer immunology research training at Memorial Sloan-Kettering Cancer Center in New York and his internal medicine training at The Johns Hopkins Hospital. He earned his medical and bachelor's degrees from Vanderbilt University and received additional research training at the National Institutes of Health. "Early detection of cancer for high-risk patients represents one of the largest unmet needs in healthcare," said Dr. Venstrom. "Due to their remarkable sensitivity and specificity, ClearNote Health's blood-based tests have the potential to fundamentally shift oncology from late-stage intervention to proactive early detection. I am excited to work with leading clinicians, health systems, and researchers to generate the rigorous evidence required to establish our tests as new standards of care." Advancing Regulatory and Quality Excellence Ms. Hsieh's promotion to vice president of regulatory affairs and quality assurance comes at a pivotal time as ClearNote Health advances discussions with regulatory authorities and prepares for expanded clinical studies. In her new role, she will lead regulatory submissions, quality oversight, and cross-functional alignment to ensure the company's platform meets the highest clinical and regulatory standards. Ms. Hsieh has more than 17 years of experience in global regulatory strategy, quality systems implementation, and compliance in complex diagnostic environments at leading diagnostics and pharmaceutical organizations, including Revvity, ChromaCode, Thermo Fisher Scientific, Shire, and Abbott. Ms. Hsieh earned a bachelor of science degree from the University of California, San Diego, and a master of science degree from San Diego State University. Accelerating Global Commercial Adoption Dr. Black joins ClearNote Health as general manager of international markets, bringing a successful history of scaling innovative diagnostics and biotech solutions from early-stage development to international market adoption. He will oversee global go-to-market strategy, business development, partnership management, and market access initiatives to accelerate the commercial expansion of ClearNote Health's epigenetic-based early cancer detection portfolio. He has 20 years of experience in international commercial leadership across the biotech and medtech sectors, having held senior roles at Centogene and Roche Diagnostics, with increasing responsibility across global marketing, product management, and strategic partnerships. Dr. Black earned a bachelor of science degree and a master of business administration degree from the Graduate School Rhein-Neckar in Mannheim, Germany, along with a doctor of business administration from Warsaw Management University in Warsaw, Poland. Mr. Bennett joins ClearNote Health as head of marketing, bringing a track record of scaling innovative healthcare technologies from early commercialization to international adoption. He will oversee brand strategy, go-to-market execution, provider engagement, and patient education initiatives. Previously, Mr. Bennett was the vice president of marketing at iCAD, a global leader in AI-powered breast health solutions. Prior to that, he spent more than 16 years at Myriad Genetics, serving in senior marketing positions across imaging, oncology, and women's health. Mr. Bennett earned a bachelor of science degree from the Pennsylvania State University and a master of science degree from the University of Utah. ClearNote Health's leadership expansion occurs as the company builds on the recent success of its enhanced Avantect(R) Pancreatic Cancer Test. Designed as a simple blood-based test, the ClearNote Avantect tests are intended for patients at elevated risk of cancer. They feature an integrated, multianalyte, multiomic approach with optimized machine learning algorithms. With the high overall cancer detection sensitivity and specificity, the Avantect tests help clinicians to identify early-stage cancers sooner, enabling more informed and timely clinical management decisions.[1] About ClearNote Health ClearNote Health is a privately held company dedicated to improving early detection and monitoring for some of the deadliest forms of cancer. Developed by scientists in the Stephen Quake laboratory at Stanford University, the company's patented core Virtuoso(TM) epigenomics platform builds on the latest advances in artificial intelligence and bioinformatics to measure active biological differences between cancer and healthy cells in a blood sample. Its highly sensitive, noninvasive Avantect(R) pancreatic and ovarian tests may identify cancers in high-risk patient populations earlier than conventional approaches, when patients may be more likely to benefit from treatment. The company's multi-cancer detection test was recently selected as one of two blood-based technologies for the National Cancer Institute's Vanguard Study. ClearNote Health's headquarters and CLIA-certified, CAP-accredited and New York State Department of Health-approved laboratory are located in San Diego. For more information, visit www.clearnotehealth.com or follow the company on LinkedIn. References [1] Data on file ClearNote Health, the ClearNote Health logo, and Avantect are registered trademarks of ClearNote Health. The Avantect Test has not been cleared or approved by the U.S. Food and Drug Administration.