Scientist I

How will your role help us transform hope into reality?

You will have the opportunity to contribute to early drug discovery programs as well as new target identification and validation to expand our drug discovery pipeline. This position offers the unique opportunity to directly impact a growing portfolio of targeted therapies in a fast-paced and innovative research environment. Your work will support Blueprint Medicines to bring next-generation treatments to benefit the right patients.

What will you do?

• Lead from the bench to identify and validate novel targets within the oncology and/or immunology & inflammation space to grow Blueprint’s pipeline
• Independently conduct, optimize and proactively troubleshoot cellular screening assays to support early-stage small molecule inhibitor or protein degrader drug discovery programs
• Proactively employ a breadth of cell and molecular biology techniques, including gene targeting approaches and small molecule inhibition, to dissect mechanism of action
• Design and execute experiments to evaluate target dependency, phenotypic responses, resistance mechanisms, and drug combinations
• Process, interpret, and present data to cross-functional team members to contextualize findings for the broader program
• Perform other responsibilities as assigned.

What minimum qualifications do we require?

• BS with 8+ years of experience in industry, M.S. with 5+ years of experience in industry or a PhD

What additional qualifications will make you a stronger candidate?

• Highly skilled in standard laboratory techniques (e.g. mammalian cell culture) and a wide range of state-of-the-art molecular and cellular biology techniques (e.g. RT-qPCR, flow cytometry, immune-assays, AlphaLISA, In-Cell Western, high content imaging (HCI), CRISPR gene editing, etc)
• Ability to independently execute experiments to investigate the mechanism of action, efficacy and safety of potential therapeutic targets using genetic and pharmacological approaches
• Familiarity with PK/PD/efficacy relationships and experience delivering PD readouts is a plus
• Ability to identify, learn, and adapt to new technologies as they become available
• Strong oral and written communication skills, as well as excellent documentation and organizational skills
• Familiarity with standard software analytical tools (e.g. GraphPad Prism, FlowJo, Excel, etc)
• Excellent time management skills, and comfortable with multi-tasking to thrive in a fast-paced environment and meet deadlines
• Self-motivated, creative scientist with a strong “can-do” attitude
• Strong problem solving and interpersonal skills to facilitate cross-functional collaboration. A team player, who listens effectively, invites response and discussion
• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equal Employment Opportunity

At Blueprint Medicines, we foster an environment of fair treatment and full participation for all of our employees as we navigate complex challenges in pursuing our mission to improve the lives of patients. We celebrate our unique differences and varied career and life experiences so that we can sustain our diverse culture and ensure everyone feels accepted. We are committed to non-discrimination, equal employment opportunity, as well as an inclusive recruitment process. We consider all qualified applicants based on merit and without regard to race, color, sex, gender identity, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable federal or state law.

We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to [email protected]. We are also an E-Verify Employer. For more information, please see our EEO Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and/or the EEO Know Your Rights Poster.

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

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