Who we are:

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on delivering oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Kymera is also progressing degrader oncology programs that target undrugged or poorly drugged proteins to create new ways to fight cancer. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn.

How we work:

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

How you’ll contribute:

You will use cryo-EM to determine high resolution structures of protein complexes of therapeutic interest. You will have the opportunity to learn the state-of-art of single particle cryoEM from sample preparation to data processing and apply cryo-EM workflow to determine structures of TPD ternary complexes and/or ubiquitination assembly. You can look forward to gaining firsthand experience in biotechnology and expand your drug discovery knowledge through interaction with a variety of scientists and cross-functional teams.

• Design and perform experiments to assemble, characterize, and prepare protein complexes.
• Prepare and screen cryo-EM samples, collect cryo-EM data, and determine cryo-EM structures for protein complexes.
• Collaborate with colleagues, including co-facility managers and CRO in cryo-EM data collection.
• Meet with mentor to discuss action items, participate in group meetings, and present structure data and analysis in group meetings and project meetings.

Skills and experience you’ll bring:

• Currently pursuing a MS or a PhD degree in a biology, biochemistry, biophysics, or related field.
• Completed graduate coursework in biochemistry, chemistry, and structural biology.
• Hands-on laboratory experience in protein science and/or structural biology (X-ray crystallography or cryoEM) as part of thesis project.
• Experience in protein purification (e.g AKTA) and structure analysis software is required.
• Experience in one or more structural biology methods (X-ray crystallography/cryo-EM, NMR) and Linux machine is highly desirable.
• Ability to work well in a collaborative team environment. Comfortable in presenting result to small group and cross function team.

Skills and experience not an exact match?:

Go ahead and submit your resume (and a cover letter, if you’d like!).  If this role isn’t right for you, we can keep you in mind for future opportunities.

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.