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Senior Scientist
Process & Formulation Science
Confirmed live in the last 24 hours
Locations
Cambridge, MA, USA
Experience Level
Entry
Junior
Mid
Senior
Expert
Requirements
  • PhD or MS in Pharmaceutical Sciences, Chemical engineering, Bioengineering or related field. PhD with 4+ or MS with 8+ years of drug product and CMC development experience
  • Deep understanding of lipid nanoparticle formulation for gene therapy products. Prior industry research experience especially in nucleic acids and drug delivery is preferred
  • Familiarity with ultrafiltration and aseptic unit operations for sterile drug product manufacture
  • Experience using statistical computer languages (R, Python, SLQ, etc.) to manipulate data and draw insights from large data sets. Knowledge of statistical techniques and concepts (regression, properties of distributions, statistical tests, and proper usage, etc.)
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change
  • Passion for science and strong work ethic
Responsibilities
  • Support development of an automated process with active analytics and process feedback for lipid nanoparticle production across mixing geometries, scales, components, and payloads
  • Design and execute experiments to enable a robust formulation and reproducible process for manufacture of clinical trial materials
  • Design and execute experiments to evaluate and optimize stability of RNA, LNP and viral vectors
  • Collaborate with LNP discovery, Lead optimization, Vector Production, Technical Development, and Analytical groups
  • Provide support with tech transfer activities for manufacturing of drug product
  • Generate high quality documentation as per Beam SOPs and in support of regulatory filings
  • Communicate scientifically rigorous findings via verbal and written communications, and presentations both internally and externally
Beam Therapeutics

501-1,000 employees