Full-Time
Posted on 10/31/2025
Develops and commercializes safer cell therapies
$170k - $220k/yr
Menlo Park, CA, USA
In Person
Orca Bio develops and commercializes cell therapies to improve outcomes for patients. It works by researching, developing, and producing therapies that use the body’s own cells to treat diseases, with products sold to healthcare providers who administer them to patients. The company aims to enhance the safety and effectiveness of cell therapies, making treatments more reliable for conditions that lack good options. Orca Bio differentiates itself through its focus on delivering safer, more effective therapies and by fostering a strong team culture with active stakeholder communication, including a regularly updated newsroom. Overall, its goal is to expand access to improved cell therapies and become a leading player in the cell therapy market.
Company Size
201-500
Company Stage
Debt Financing
Total Funding
$542M
Headquarters
Menlo Park, California
Founded
2016
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Unlimited Paid Time Off
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FDA review not plain sailing for Orca. 2 April 2026 Privately-held US cell therapy company Orca Bio announced that the US Food and Drug Administration (FDA) has extended the review timeline of its Biologics License Application (BLA) for Orca-T for the treatment of patients with hematologic malignancies. This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here. Try before you buy Free. 7 day trial access * All the news that moves the needle in pharma and biotech * Exclusive features, podcasts, interviews, data analyses and commentary from its global network of life sciences reporters. * Receive The Pharma Letter daily news bulletin, free forever. Become a subscriber £820. Or £77 per month * Unfettered access to industry-leading news, commentary and analysis in pharma and biotech. * Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results. * Daily roundup of key events in pharma and biotech. * Monthly in-depth briefings on Boardroom appointments and M&A news. * Choose from a cost-effective annual package or a flexible monthly subscription The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It's part of the key information for keeping me informed Chairman, Sanofi Aventis UK More on this story... 23 March 2026 25 March 2026 1 April 2026 Companies featured in this story. Sign up to receive email updates Join industry leaders for a daily roundup of biotech & pharma news Today's issue. 2 April 2026 Company spotlight. A clinical-stage biotechnology company developing atacicept and other targeted therapies for serious immunological and kidney diseases with high unmet medical need. More features in biotechnology. 2 April 2026
Orca Bio announces $250M in aggregate financing to support launch readiness leading up to the Orca-T® PDUFA date of April 6, 2026.
Orca Bio secures $250 million in financing. MENLO PARK - Orca Bio, a late-stage biotechnology company committed to transforming the lives of patients through high-precision cell therapy, has completed a Series F financing round led by Lightspeed Venture Partners. With $250 million in new equity capital from its two most recent financing rounds, along with a 2025 amendment to its Silicon Valley Bank credit facility providing up to $100 million in additional liquidity, Orca Bio possesses the financial strength to scale its commercial operations and advance its clinical pipeline. The proceeds will be used to ensure commercial readiness as the company approaches the April 6, 2026 Prescription Drug User Fee Act (PDUFA) target action date for Orca-T, Orca Bio's lead investigational allogeneic T-cell immunotherapy. The funding will help strengthen the company's infrastructure to support future commercial scale, including the addition of East Coast manufacturing capacity to complement its Sacramento, CA operations. The capital will also support the accelerated advancement of Orca Bio's pipeline across multiple clinical programs designed to expand treatment to more patients in need.
Orca Bio has raised $250 million across two funding rounds to prepare for the commercialisation of its blood cancer cell therapy Orca-T. The California-based biotech also secured up to $100 million in credit from Silicon Valley Bank. Orca filed for FDA approval of Orca-T last year, with a decision expected by 6 April. The allogeneic T-cell immunotherapy uses purified donor regulatory T cells to prevent graft-versus-host disease with less immunosuppression than conventional transplantation methods. A phase 3 trial showed significantly better survival outcomes compared to standard tacrolimus and methotrexate treatment. The funding will support manufacturing expansion, including new East Coast capacity. Mike Hirschmann, formerly of Legend Biotech, now leads commercial operations following leadership changes last year.
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