Full-Time

Clinical Genomics Scientist I

Posted on 2/3/2025

Helix

Helix

501-1,000 employees

Integrates genomics into healthcare solutions

Biotechnology
Healthcare

Compensation Overview

$78k - $120kAnnually

+ 10% Annual Bonus + Equity

Junior, Mid

Remote in USA

Candidates must be based in the United States.

Category
Genomics
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis

You match the following Helix's candidate preferences

Employers are more likely to interview you if you match these preferences:

Degree
Experience
Requirements
  • MS or PhD degree with expertise in molecular genetics, human genetics, molecular pathology, or related fields.
  • At least 2+ years of experience in clinical variant classification preferably in one or more of the following disease areas: Cardio, Epilepsy, Parkinson’s and Polycystic Kidney Disease.
  • Working knowledge of ACMG/AMP Variant Classification Guidelines and their modifications by ClinGen expert panels.
  • Familiarity with human mutation databases, genome browsers, HGVS nomenclature, and in-silico variant pathogenicity predictors.
  • Able to perform technical writing, as well as strong communication and computer skills.
  • Excellent analytical skills and attention to detail.
  • Able to critically read and distill data from the scientific literature.
  • Must be able to adjust to shifting priorities according to workload or business needs.
  • Able to critically assess and augment processes and workflows.
Responsibilities
  • Be responsible for variant and gene assessments including researching the significance of variants in published literature and clinical data, evaluating evidence for gene-disease associations, and performing data review.
  • Perform technical review of sequencing data derived from NGS, including genome, exome, panel, and single-site variant data, as well as other molecular assay data.
  • Troubleshoots complex cases.
  • Compile interpretive variant summaries and contribute to clinical report writing.
  • Contribute to in-house interpretation workflow development of process documentation.
  • Communicate clearly with internal and external stakeholders, such as genetic counselors, physicians, lab staff, and product developers.
  • Maintain laboratory variant knowledgebase and assists with curation and harmonization of variant classification changes over time.
  • Perform variant classification quality controls and maintain quality management programs according to written policies and procedures.
  • Actively participate in continuing education series including journal clubs, complex variant discussions/presentations, and conferences, as needed.
  • Train junior team members, as needed.
  • Contribute to research projects as necessary.
Desired Qualifications
  • Experience with gene-disease validity curations based on ClinGen protocols.
  • Familiarity with Integrative Genomics Viewer.
  • Experience in cardio and/or cancer disease area.

Helix focuses on integrating genomics into healthcare to enhance patient care and drive growth for health organizations. They provide solutions that make genomic data accessible and actionable, allowing clients like health systems and life science companies to offer personalized healthcare at scale. Their services improve patient outcomes and reduce costs, creating strategic value for their clients. Helix also contributes to medical research by providing insights that accelerate the development of therapies and improve diagnosis and treatment. They operate a large clinical Next-Generation Sequencing (NGS) lab, which enables efficient genetic analysis and supports public health efforts in disease monitoring and outbreak response. Helix's goal is to transform healthcare through the power of genomics.

Company Stage

Series C

Total Funding

$399.8M

Headquarters

San Mateo, California

Founded

2015

Growth & Insights
Headcount

6 month growth

-1%

1 year growth

-2%

2 year growth

-1%
Simplify Jobs

Simplify's Take

What believers are saying

  • Helix's AI model predicts semaglutide weight loss response, enhancing personalized treatment plans.
  • The Helix Research Network is the largest precision clinical research network globally.
  • Partnership with Komodo Health enriches Helix's datasets with comprehensive patient-level insights.

What critics are saying

  • Data privacy concerns may arise from expanding clinico-genomic datasets with Komodo Health.
  • Rapid network expansion could strain Helix's resources and affect service quality.
  • Skepticism towards AI-driven healthcare solutions may hinder clinical adoption of Helix's models.

What makes Helix unique

  • Helix operates one of the largest CLIA/CAP next-generation sequencing labs globally.
  • Their proprietary Exome+™ assay offers comprehensive genomic insights for clinical care.
  • Helix's clinico-genomic datasets integrate genomic data with longitudinal EHR data.

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Benefits

Health Insurance

Parental Leave

401(k) Company Match

401(k) Retirement Plan

Unlimited Paid Time Off

Remote Work Options

Home Office Stipend