Full-Time

Associate Scientist

Confirmed live in the last 24 hours

Arcellx

Arcellx

51-200 employees

Develops immunotherapies for cell therapy

Biotechnology
Healthcare

Compensation Overview

$72k - $78kAnnually

+ Bonus + Equity Grant

Junior, Mid

North Bethesda, MD, USA

Relocation assistance offered if required.

Category
Genomics
Biology Lab & Research
Biology & Biotech
Required Skills
PowerPoint/Keynote/Slides
Requirements
  • BS degree with 2+ years of full-time laboratory experience or thesis-based MS degree.
  • Familiarity with one or more of the following areas: cell therapy, T-cell biology, tumor immunology or the use of biologics in anti-cancer therapy.
  • Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion.
  • Proficiency with complex immune cell assays including multiparameter flow cytometry, in vitro cell based assays, and multiplex assays.
  • Ability to effectively multitask and collaborate across multiple projects in a fast-paced cross-functional environment.
  • Commitment to ethical scientific investigations and rigorous experimental methods.
Responsibilities
  • Handle, isolate and manipulate primary human immune cells (e.g. PBMC, BMMC, T cells and monocytes) and cultured cell lines.
  • Produce research-scale lentivirus, analyze lentiviral quality, and determine viral integration into cell lines or primary human T-cells.
  • Conduct complex immune assays including in vitro cell-based assays (e.g. cytotoxicity, proliferation, degranulation), multiplex assays (e.g. MSD) and live cell analysis (e.g. Incucyte).
  • Flow cytometry acquisition and analysis to evaluate antigen expression and protein binding.
  • Process blood and tissues from animal studies for analysis.
  • Execute ELISAs (commercial kits and custom assays) to measure cytokines, proteins and/or other biomarkers.
  • Utilize common software including GraphPad Prism, Word, PowerPoint, Excel, Outlook, and Flow Cytometry Analysis Software (FlowJo) to analyze, record and present your results.
  • Communicate detailed observations on experiments and assist in the preparation of technical reports, summaries, and protocols.
  • Work both independently and collaboratively, and effectively plan, organize work activities, and prioritize task completion.
  • Assist in maintaining laboratory consumables.

Arcellx develops immunotherapies aimed at improving cell therapy for serious diseases. Their products focus on advanced techniques that enhance the effectiveness of treatments. The company collaborates with healthcare providers and research institutions to bring these therapies to patients. Unlike many competitors, Arcellx emphasizes proprietary products and partnerships to drive their research and development efforts. The goal is to meet unmet medical needs by providing safe and effective treatment options through their innovative approach to cell therapy.

Company Stage

IPO

Total Funding

$194.5M

Headquarters

Gaithersburg, Maryland

Founded

2014

Growth & Insights
Headcount

6 month growth

18%

1 year growth

24%

2 year growth

72%
Simplify Jobs

Simplify's Take

What believers are saying

  • The Phase 3 iMMagine-3 trial for anito-cel could significantly boost Arcellx's market position if successful.
  • Recent robust long-term responses from the Phase 1 expansion trial of anito-cel indicate promising efficacy and safety, potentially leading to FDA approval.
  • The $285M equity investment and upfront cash from Kite provide substantial financial backing for Arcellx's ongoing and future projects.

What critics are saying

  • The competitive landscape for CAR T therapies is intense, with established players like Abecma and Carvykti posing significant challenges.
  • Regulatory hurdles, such as the recent FDA partial hold, could delay product development and market entry.

What makes Arcellx unique

  • Arcellx's anitocabtagene autoleucel (anito-cel) is the first BCMA CAR T therapy for multiple myeloma utilizing a novel D-Domain binder, setting it apart from existing treatments.
  • The company's strategic partnership with Kite, a Gilead Company, enhances its research capabilities and market reach, distinguishing it from smaller biotech firms.
  • Arcellx's focus on innovative immunotherapies for cancer and other incurable diseases positions it uniquely in the biotech landscape.

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