Scientist – RNA Process Development
Posted on 2/16/2023
Cambridge, MA, USA
Experience Level
  • Degree in Chemistry, Biochemistry, Chemical Engineering, or related fields with 0-2 years of relevant industry experience, or M.S. in Chemistry, Biochemistry, Chemical Engineering, or related fields with 8+ years industry experience
  • Experience purifying (anion exchange, reversed phase, size exclusion chromatography and TFF) oligonucleotides
  • Experience and/or working understanding of common techniques used to analyze oligonucleotides, such as HPLC/UPLC, UV/Fluor, CD and LC-MS
  • Strong knowledge of nucleic acid chemistry, nucleic acid structure-activity relationships and safety profiles is desirable
  • Excellent communication skills and the ability to present effectively to others with diverse scientific backgrounds
  • Desire to embrace challenges of developing novel technologies and work flexibly in a fast-paced, team-oriented environment
  • Develop and evaluate processes for the synthesis, purification, and analysis of synthetic RNAs
  • Evaluate new approaches and provide technical guidance on optimal downstream conditions to produce synthetic RNAs
  • Establish chromatographic processes to purify RNA to be used in R&D and pre-clinical manufacturing
  • Interface with Analytical Sciences, Process Development, Delivery, Pharmacology, Platform and Disease program teams
  • Author, review, and approve protocols, SOPs, technical documents, and reports for RNA chemistry lab
  • Independently plan and execute experiments, perform data analysis and interpretation
  • Deliver reproducible and impactful results in a fast-paced environment
  • Understand the landscape of clinical and process materials, liaise with vendors, and maintain appropriate inventory
  • Maintain thorough electronic lab notebooks and documentation records, and present findings to multi-disciplinary teams in various oral and written formats
  • Adhere to all laboratory safety requirements and procedures, assist in maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies
Desired Qualifications
  • Experience purifying biomolecules on an AKTA chrom system is a plus
Beam Therapeutics

501-1,000 employees