Full-Time

US: Associate Director

Viral Vector Sciences

Posted on 8/2/2024

Legend Biotech

Legend Biotech

1,001-5,000 employees

Develops and commercializes cell therapies

Biotechnology
Healthcare

Senior, Expert

Somerset County, NJ, USA

Hybrid position requiring some in-office presence.

Category
Bioinformatics
Computational Biology
Genomics
Public Health
Biology Lab & Research
Biology & Biotech
Required Skills
Data Analysis
Requirements
  • BS/MS/Ph.D. (or relevant experience) in cell biology, molecular biology, immunology, virology, biomedical engineering or other related sciences preferred
  • 8+ years of experience in viral vector development, production, and analytics
  • Understanding of molecular biology, viral vectors, and viral vector-based assays
  • Expertise in viral vector production (lentiviral, retroviral, or adeno-associated virus) and technology transfer
  • Understanding of plasmid production and testing is a plus
  • Experience in CDMO evaluation and working with external partners
  • Understanding of health authority regulations related to viral vectors
  • Facilitating a multifunctional and multicultural network
  • Knowledge of cGLP/cGMP guidelines
  • Detail-oriented, excellent organizational skills with expertise in problem solving and solid decision-making abilities
  • Strong written and verbal communication skills are essential
  • Ability to operate independently and in a team environment
  • English/Mandarin preferred
Responsibilities
  • Oversee production and testing of lentivirus, retrovirus, and/or AAV at the research, process development or GMP production scale for use in clinical cell and gene therapy project activities
  • Support the evaluation of new CDMO technical capabilities, assist in testing and technical changes, and provide support with CDMOs for execution of development and early clinical project activities
  • Responsible for technical and organizational leadership in tech transfer of a commercial vector; in collaboration with tech transfer project manager, drive, and tack document transfer
  • Responsible for designing the viral vector process and analytical tech transfer strategy and monitoring timelines
  • Collaborate with quality to ensure GMP practices are followed by external partners and implement appropriate controls
  • Conduct technical discussions & meetings with internal and external stakeholders and facilitate implementation of new viral vector technologies
  • Troubleshooting viral vector production process and analytical issues of commercial processes, as well as and proactivity identify and mitigate risks and weaknesses
  • Coordinate, author, and review technical documents, protocols, and reports, including providing SME support to regulatory for USA, China and EU regulatory filings
  • Some travel required

Legend Biotech develops and commercializes cell therapies aimed at treating serious diseases, particularly cancers like hematological malignancies and solid tumors. Their approach is technology agnostic, allowing them to explore various methods to find effective treatments. The company operates in the personalized medicine sector, focusing on discovering, developing, and bringing new therapies to market. They generate revenue through licensing and selling their therapies, including CAR-T therapies, which involve modifying a patient's cells to combat cancer. Legend Biotech emphasizes transparency with investors, regularly updating them on financial results and business developments.

Company Stage

IPO

Total Funding

$146.4M

Headquarters

Franklin Township, New Jersey

Founded

2014

Growth & Insights
Headcount

6 month growth

0%

1 year growth

-1%

2 year growth

0%
Simplify Jobs

Simplify's Take

What believers are saying

  • Recent FDA and European approvals for CARVYKTI® expand its market reach in multiple myeloma.
  • New R&D facility in Philadelphia boosts innovation in next-generation cell therapies.
  • Alan Bash's appointment could accelerate CARVYKTI®'s growth and market penetration.

What critics are saying

  • Increased competition from Amgen's Imdelltra may impact CAR-T therapy focus.
  • Collaboration with Multiply Labs may face technological challenges, delaying production timelines.
  • Financial strain from new R&D facility could affect operational focus if advancements lag.

What makes Legend Biotech unique

  • Legend Biotech focuses on novel cell therapies for oncology, including CAR-T and NK cells.
  • The company is technology agnostic, exploring multiple platforms for effective cancer treatments.
  • Legend Biotech's CARVYKTI® is the first BCMA-targeted CAR-T therapy approved for second-line use.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Paid Sick Leave

Paid Holidays

Remote Work Options

INACTIVE