Full-Time

Scientist – Bioassay Development

Denali Therapeutics

Denali Therapeutics

201-500 employees

Develops therapies for neurodegenerative diseases

Biotechnology

$121,000 - $158,000

401k, ESPP

Junior, Mid, Senior

San Bruno, CA, USA

Requirements
  • BS./M.S. in relevant scientific discipline with a minimum of 5 8 years of direct CMC bioassay development experience in biotech/biopharma or Ph.D. with 2+ years of directly relevant experience
  • Direct experience performing, developing and optimizing bioassays using multiple platforms and technologies (e.g., ELISA, HTRF, DELFIA, fluorescence etc.) is required.
  • Experience in developing and optimizing cell-based assays using different bioassay methodologies (e.g., cellular uptake, reporter gene, effector function) is preferred.
  • Hands on experience in developing binding and cell-based assays measuring biological activity within large molecule CMC function is desired.
  • Working with electronic notebooks and experience with graphing or statistical packages (GraphPad Prism, SoftMax Pro, PLA, etc.) is essential.
Responsibilities
  • Independently design and perform experiments with a focus on binding, enzymatic activity, and cell-based bioassays.
  • Developing, optimizing, and qualifying bioassays for product release and stability testing as well as to supporting cell-line, bioprocess, and formulation development activities.
  • Serve as subject matter expert (SME) for potency assays, promoting innovation and exploring novel techniques or technology and approaches for developing, optimizing, qualifying, and troubleshooting of complex assays.
  • Responsible for leading and supporting testing for extended characterization studies of early and late-stage projects.
  • Maintaining complete and accurate records and contribute to continuing process improvement.
  • Representing Bioassay team cross-functionally and continuously drive Bioassay method development through internal and external collaborations.
  • Presenting experimental results in team meetings.
  • Detailed recording and analysis of experiments in an electronic laboratory notebook (ELN)
  • Coordinating parallel tasks across multiple projects and prioritizing deliverables to meet departmental and organizational goals.

Denali Therapeutics stands out as a leader in the field of neurodegenerative diseases, leveraging recent scientific insights into genetic causes and biological processes to develop effective treatments for conditions like Alzheimer's, Parkinson's, and ALS. The company's culture is characterized by a commitment to rigorous science, translational medicine, and collaboration, fostering an environment where diverse backgrounds and experiences unite behind the shared goal of defeating degeneration. Denali's competitive advantage lies in its deep expertise in neurodegenerative disease biology and the blood-brain barrier, which informs a robust portfolio of programs at various stages of clinical and preclinical development, all aimed at improving patient lives by addressing disease causes or risk factors.

Company Stage

N/A

Total Funding

$1.1B

Headquarters

South San Francisco, California

Founded

2015

Growth & Insights
Headcount

6 month growth

-8%

1 year growth

-5%

2 year growth

7%