Full-Time

Research Associate

Lab Automation and Screening

Posted on 8/22/2024

Alltrna

Alltrna

51-200 employees

Develops tRNA therapeutics for disease treatment

Biotechnology
Healthcare

Entry

Cambridge, MA, USA

Category
Lab & Research
Life Sciences
Required Skills
Communications
Word/Pages/Docs
PowerPoint/Keynote/Slides
Requirements
  • Bachelor’s degree in Biology, Biochemistry, Molecular Biology or a related field with direct experience working in a laboratory environment
  • Hands-on experience with mammalian cell culture and transfections
  • Hands-on experience with nucleic acid extraction
  • Strong written and verbal communication skills and excellent attention to detail
  • Strong teamwork skills and ability to work in a fast-paced environment
  • Desire to learn about and implement new technologies
  • Knowledge of programs such as Microsoft Word, PowerPoint, Excel, and GraphPad Prism
Responsibilities
  • Maintain mammalian cell cultures using aseptic technique and executing cell-based assays
  • Follow standardized protocols for high to medium throughput assays, with attention to detail
  • Support high-throughput cell-based assay development; and perform cellular/molecular biology techniques including the generation of stable reporter cells, enzymatic assays, and NGS-assays.
  • Assist in processing of in vitro and in vivo samples for sequencing.
  • Document experiments, analyze data, and report results using electronic laboratory notebooks and effectively communicate findings in lab meetings
  • Execute and optimize processes within the lab to increase efficiency and effectiveness, including managing biologics inventory, lab consumables, chemicals, and equipment

Alltrna focuses on developing tRNA therapeutics to treat diseases caused by genetic mutations. Their main product involves engineered tRNAs that can recognize and read stop codons, which are errors in the genetic code that lead to the production of incomplete proteins. By delivering the correct amino acids, these tRNAs help restore the production of full-length proteins, potentially addressing a wide range of diseases linked to nonsense mutations. Unlike other biotech companies, Alltrna is the first to explore the therapeutic potential of tRNA in this way, aiming to unlock new treatment options for patients with specific genetic disorders. The goal of Alltrna is to provide effective treatments that target the root causes of diseases, improving the quality of life for those affected.

Company Stage

Series B

Total Funding

$154.7M

Headquarters

Cambridge, Massachusetts

Founded

2018

Growth & Insights
Headcount

6 month growth

0%

1 year growth

-1%

2 year growth

1%
Simplify Jobs

Simplify's Take

What believers are saying

  • Raised $109M in Series B to advance tRNA medicines for Stop Codon Disease.
  • Growing market interest in RNA technologies supports Alltrna's innovative approach.
  • FDA's fast-tracking of RNA therapies suggests favorable regulatory conditions for Alltrna.

What critics are saying

  • Potential competition from established RNA-based therapy companies like Moderna.
  • Complexity of tRNA biology may pose challenges in clinical translation.
  • High development costs could strain resources despite recent funding.

What makes Alltrna unique

  • Alltrna is the first to decode tRNA biology for therapeutic use.
  • Their platform uses AI/ML to develop programmable molecules for disease treatment.
  • Alltrna targets nonsense mutations, restoring full-length protein production in genetic diseases.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Parental Leave

Unlimited Paid Time Off

401(k) Retirement Plan

Disability Insurance

Life Insurance

Commuter Benefits

Professional Development Budget

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