Senior Manager

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

We are seeking an accomplished Senior Manager AI Engineering to provide technical leadership for a team of AI and machine learning engineers driving the next generation of AI solutions. In this pivotal role, you will contribute to the shape and execution of the R&D organization’s AI strategy, including the end-to-end development of robust, scalable models and platforms. Your expertise will ensure the successful deployment of cutting-edge AI technologies while fostering a strong, data-driven culture of innovation and excellence.

Essential Functions of the Job:

• Lead AI Development – Take the technical leadership of the design, build, and deployment of advanced AI/ML solutions aligned with business and scientific goals.

• Collaborate Broadly – Partner with engineers, data scientists, and product teams to integrate models into production workflows.

• Set Standards – Promote best practices for development, testing, deployment, and ongoing model performance.

• Drive Innovation – Track emerging AI technologies and introduce new tools to keep the team at the forefront.

• Ensure Compliance – Maintain strict data privacy, security, and ethical standards.

Foundational Background

• Experience: 5+ years of progressive AI/ML engineering experience, including driving large-scale AI initiatives and collaboration with diverse high-performing engineering teams.

• Track Record: Proven success delivering production-grade, scalable AI/ML solutions that create measurable scientific or business impact.

Core Technical Expertise

• Generative AI Leadership: Deep, hands-on experience in training, fine-tuning, hosting, and deploying large-scale generative models, with mastery of PyTorch (preferred) or TensorFlow for model development and optimization.

• Agentic AI Frameworks: Demonstrated expertise in Agentic AI design and orchestration, leveraging frameworks such as LangGraph, LangChain, or similar to build intelligent, multi-step reasoning agents.

• Advanced AI Techniques: Strong capability in context engineering, prompt engineering, agent- or graph-augmented retrieval (Agent/Graph RAG), text-to-SQL generation, and multimodal AI (integrating text, image, structured data, etc.) to enable complex knowledge-driven applications.

• MLOps & Infrastructure: Robust knowledge of MLOps best practices, including CI/CD pipelines for machine learning, model versioning, automated testing, scalable deployment, and cloud platforms (AWS, Azure, GCP).

Life Sciences & Biomedical AI

• Domain-Specific Modeling: We prefer familiarity with biomedical and pharmaceutical NLP technologies such as cTAKES, BioGPT, PubMed-based LLMs, or similar biomedical AI frameworks.

• Knowledge Systems: Experience applying knowledge graphs and ontology-driven reasoning to drug discovery, clinical data integration, or molecular research is a strong plus.

Leadership & Collaboration

• Exceptional ability to Lead and partner with cross-functional technical teams, mentor other engineers, and drive alignment with scientists, product leaders, and business stakeholders.

• Superior communication skills for conveying complex AI concepts to diverse audiences, including research, regulatory teams.

• Deep appreciation of data privacy, security best practices, and ethical considerations in AI development and deployment.

Education Required:

• Bachelor’s or Master’s degree in Computer Science, Artificial Intelligence, Data Science, Engineering, or a closely related technical field (Ph.D. preferred).

BeOne Global Competencies:

When we exhibit our values of Patients First, Collaborative Spirit, Bold Ingenuity and Driving Excellence, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork

• Provides and Solicits Honest and Actionable Feedback

• Self-Awareness

• Acts Inclusively

• Demonstrates Initiative

• Entrepreneurial Mindset

• Continuous Learning

• Embraces Change

• Results-Oriented

• Analytical Thinking/Data Analysis

• Financial Excellence

• Communicates with Clarity

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process.  Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [email protected].