Research Sr. Scientist

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Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide.

About the Role:

The Gastrointestinal and Inflammation (GI2) Drug Discovery Unit at Takeda is building a new team of experienced, innovative, and collaborative researchers to deliver an industry-leading portfolio of drugs for various gastrointestinal, autoimmune, and inflammatory diseases. We seek skilled bench scientists to join our cross-functional discovery teams.

• Generate and execute preclinical development strategies to support candidate selection and mechanistic characterization, facilitating efficient clinical validation of impactful medicines for patients with inflammatory and autoimmune disorders
• Begins at the conception of new projects
• Apply deep scientific expertise in immunology and/or cell biology to creatively mature innovative novel concepts within our team, in matrixed collaboration with other Takeda scientists, and external partners. 
• Drive an inclusive, open, and effective culture in a fast-growing drug discovery group.

Accountabilities:

• Design, perform, and interpret in vitro and ex vivo studies to evaluate drug candidate mechanisms of action
• Generate data packages supporting candidate selection and asset characterization, leveraging subject matter expertise, technical literature, and awareness of current industry standards.
• Champion scientific integrity and rigor in data analysis, preparation, and interpretation of detailed protocols/SOPs and technical reports.
• Collaborate productively within a matrixed structure, clearly communicate results, challenges, and impact in presentations and conversations with broad audiences.  Integrate data generated from other disciplines.   

Education & Competencies (Technical and Behavioral):

• PhD degree with 2+ years industry experience, or MS with 8+ years’ experience, or BS with 10+ years’ experience.
• Preferred 6+ years of industry experience
• Proven track record in inflammation research and solving complex biology problems, experience in Inflammatory Bowel Disease research is a plus.
• Strong experimental design, troubleshooting, and data analysis skills are required.
• Strong expertise in molecular biology and/or immunology with strong technical skills that include development of cell-based and biochemical assays; required skills include gene editing (CRISPR or siRNA), cell culture including work with primary immune cells, cytokine analysis (AlphaLISA, MSD, ELISA), and flow cytometry etc.
• Experience developing in vitro assays characterizing small molecule and biologics  potency and mechanism of action 
• Excellent written and verbal communication skills and the ability to work effectively in a highly-matrixed environment
• Keeps up with the latest scientific advancement and literature (e.g. competitive landscape, new technology)

This position is currently classified as “onsite” in Cambridge, MA.

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$137,000.00 - $215,270.00

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations

Boston, MA

Worker Type

Employee

Worker Sub-Type

Regular

Time Type

Full time

Job Exempt

YesIt is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.