Director – Process Chemistry

How will your role help us transform hope into reality?

As a recognized expert in drug substance development and manufacturing, you will enable advancement of Blueprint Medicines' clinical and commercial programs. You will be expected to consistently demonstrate technical leadership by obtaining and interpreting data to build longer-term scientific understanding, and strategic leadership to strengthen Blueprints' overall process chemistry capabilities and business initiatives. You will be responsible for supporting the design, development, and implementation of clinical and commercial drug substance processes to ensure a robust process and manufacturing understanding are established to achieve key deliverables on the program including drafting the regulatory submission documents and responding to agency questions to support the program milestones. You will also be expected to represent Process Chemistry on cross-functional teams and/or lead cross-functional teams within Blueprint. You will also serve as a strong mentor and expert to the process chemistry team and to the wider organization.

What will you do?

• Demonstrates advanced intellectual and technical leadership
• Leads peers scientifically with consistently excellent experimental design and productive innovation with a record of successful initiatives and excellent understanding of related scientific disciplines
• Assesses data integrity to provide expert interpretation and recommendations to project teams
• Effectively manages CDMOs/CROs, their contracts and other external collaborations
• Generate ideas and champion initiatives to extend, enhance and diversify Process Chemistry's capabilities and the wider organization
• Presents clearly and persuasively to all parts of the Blueprint organization and to our collaborators
• Coordinates and authors publications, patents, and regulatory submissions as well as external communications
• Provides strategic direction and scientific leadership for multidisciplinary CMC project teams, manage timelines, milestones, budgets, and objectives
• Assists in the development and communication of department goals and strategy
• As a people manager within the organization, supervises, mentors, and guides the career development of staff
• Performs other responsibilities as assigned

What minimum qualifications do we require? 

• Master's degree or PhD in organic chemistry with 12+ experience of relevant process chemistry and drug development experience in Pharmaceutical industry
• 5+ years of supervisory/management experience

What additional qualifications will make you a stronger candidate?

• Ability to adapt to working optimally within a variety of situations; adapts to change and to changes in job demands
• Demonstrated and proven expertise and experience with process development and scale-up
• Expert knowledge of regulatory requirements in the pharmaceutical industry
• Ability to optimally express ideas in written and oral context; collaboration, team-building skills, and interpersonal skills; genuine desire to be on a team and contribute to organizational and team goals. Ability to lead with a passion and optimism to participate in a fast-paced environment characterized by rigorous science and innovative thinking
• Ability to build productive working relationships across a multi-disciplinary internal team and effectively manage CRO/CDMO and other external collaborations
• Demonstration of effective organizational and time management skills and execution
• Commitment to our Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint?

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it.

Patients are waiting. Are you ready to make the leap?

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to [email protected]. 

For more information, please see our EEO-AA Policy Statement, the E-Verify Participation Poster, the Right to Work Poster, and/or the EEO Know Your Rights Poster, as well as our Pay Transparency Statement. 

Blueprint Medicines is a global, fully integrated biopharmaceutical company that invents life-changing medicines. We seek to alleviate human suffering by solving important medical problems in two core focus areas: allergy/inflammation and oncology/hematology. Our approach begins by targeting the root causes of disease, using deep scientific knowledge in our core focus areas and drug discovery expertise across multiple therapeutic modalities. We have a proven track record of success with two approved medicines, including bringing our medicine to patients with systemic mastocytosis (SM) in the U.S. and Europe. Leveraging our established research, development, and commercial capability and infrastructure, we now aim to significantly scale our impact by advancing a broad pipeline of programs ranging from early science to advanced clinical trials in mast cell diseases including SM and chronic urticaria, breast cancer and other solid tumors.

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