Full-Time

Computational Neuroscientist

Eon Systems

Eon Systems

Compensation Overview

$130k - $170k/yr

+ Equity

San Francisco, CA, USA

Remote

Category
Biology & Biotech (2)
,
Required Skills
Python
Neural Networks
Matplotlib
NumPy
Requirements
  • Proficiency in Python, and familiarity with scientific computing libraries (NumPy, Matplotlib).
  • Experience with brain or biomechanics simulation tools (MuJoCo, the Gymnasium API, Flybody, Flygym, Brian2).
  • Knowledge of neuroscience, computational biology, or related fields. Background in Drosophila neuroscience would be ideal.
Responsibilities
  • Use existing embodied fly models (e.g., Flybody, NeuroMechFly/Flygym) to simulate Drosophila melanogaster behaviors.
  • Create compelling demonstrations of virtual flies performing tasks in a virtual environment.
  • Customize and iterate models to achieve biologically plausible behaviors.
  • Document all code and workflows to ensure reproducibility.
  • Creation of virtual environments and bodies in Drosophila, and eventually mice.
Desired Qualifications
  • PhD or equivalent qualifications in neuroscience or related field would be ideal, but is not required

Company Size

N/A

Company Stage

N/A

Total Funding

N/A

Headquarters

N/A

Founded

N/A

Simplify Jobs

Simplify's Take

What believers are saying

  • Dr. Steve Furber praises work as pretty impressive for brain emulation.
  • Proves architecture captures function, enabling scalable mouse brain emulation next.
  • Plans scan brain and body, overcoming FlyWire motor neuron tracing limits.

What critics are saying

  • FlyWire connectome lacks motor neurons, delaying mouse emulation 18-36 months.
  • Leaky integrate-and-fire ignores dendrites, obsoleting human emulation path.
  • DeepMind publishes mouse emulation first, collapsing Eon's funding in 12-24 months.

What makes Eon Systems unique

  • Eon Systems emulates 139,255-neuron fruit fly brain controlling virtual body.
  • Achieves 91% neural response accuracy using only connectivity per 2024 Nature paper.
  • Integrates NeuroMechFly v2 with MuJoCo for closed-loop sugar-seeking behaviors.

Help us improve and share your feedback! Did you find this helpful?

Your Connections

People at Eon Systems who can refer or advise you

Benefits

Remote Work Options

Competitive salary and equity

Company News

The Register
Mar 16th, 2026
Startup simulates fruit fly brain that walks, grooms, and hunts for sugar in virtual environment

San Francisco startup Eon Systems claims to have created the first digital simulation of a fruit fly brain capable of controlling a virtual body and producing recognisable behaviours. The team connected a whole-brain connectome of Drosophila melanogaster — containing 125,000 neurons and 50 million synapses — to a virtual body model using the Brian2 neural network simulator. The resulting model demonstrated fly-like behaviours including walking, antenna cleaning, and extending its proboscis when presented with sugar scent signals. Dr Steve Furber, co-creator of the ARM processor, called the work "pretty impressive". However, critics note the simulated brain doesn't operate exactly as a real fly's brain does, relying on machine learning clamped into a connectome shape. The research builds on existing work including the Flywire connectome and NeuroMechFly v2 model.