Full-Time

Senior AI Software Engineer

Agentic AI, Luma

Posted on 12/15/2025

Dotmatics

Dotmatics

501-1,000 employees

Cloud-based R&D informatics for life sciences

Compensation Overview

$145.3k - $170.9k/yr

+ Variable Pay

Boston, MA, USA

Hybrid

Category
Software Engineering (2)
,
Required Skills
FastAPI
Python
React.js
Redux.js
Jest
OpenAI
Postgres
RAG
TypeScript
Microservices
LangGraph
Observability
LangChain
DevOps
Webpack
Databricks
HTML/CSS
Requirements
  • Expert-level Python 3.11+ with deep understanding of async/await, type hints, and modern Python best practices.
  • Experience building AI agents using LangChain/LangGraph, including tool creation, step planning, function calling, retrieval workflows, and reliable agent-state management.
  • FastAPI experience building production RESTful APIs, streaming endpoints (Server-Sent Events), and async request handling.
  • Strong PostgreSQL expertise (including performance tuning and schema design) and SQLAlchemy.
  • Strong understanding of dependency injection, clean architecture, and functional programming concepts.
  • Experience designing and scaling microservices in production environments.
  • Ability to assess engineering risk, propose rollout strategies, and make high-impact architectural decisions.
  • Experience building safe execution environments and guardrails for AI decision-making.
  • Frontend development with React & TypeScript using modern hooks and state management patterns (Redux/Context).
  • Experience with Webpack Module Federation and micro-frontend architectures.
  • Ability to design responsive, maintainable UI components using SCSS/CSS.
  • Familiarity with Jest for robust frontend testing practices.
  • LangChain & LangGraph expertise for building AI agent workflows, tool orchestration, and LLM integration.
  • Proven experience building LLM-powered applications with frameworks like LangChain, LangGraph, or similar.
  • Understanding of Retrieval-Augmented Generation (RAG) patterns and vector embeddings.
  • Experience with agent orchestration, tool creation, and multi-step reasoning workflows.
  • Familiarity with LLM serving endpoints (Databricks, OpenAI, Anthropic, or similar).
  • Knowledge of streaming responses, callback systems, and real-time feedback mechanisms.
  • Understanding of Model Context Protocol (MCP) for tool integration.
Responsibilities
  • Design and implement AI agent workflows and tooling using LangChain/LangGraph, enabling AI models to plan actions, call tools, use APIs, search information, and reliably complete multi-step workflows.
  • Build and maintain the tools, function interfaces, and system connectors that AI agents use to interact with databases, document stores, enterprise apps, and external APIs.
  • Ensure AI agents operate safely, follow rules, respect permissions, and reliably execute within defined constraints.
  • Lead and execute the design and implementation of core workflow orchestration and tooling features, including automated tasks and background processes.
  • Build scalable FastAPI services with well-defined RESTful APIs and real-time streaming endpoints.
  • Create modular, reusable service components with strong authentication, error handling, and pagination patterns.
  • Develop and guide React frontend components for real-time interactions and data visualization.
  • Implement multi-tenant architecture with secure isolation, resource boundaries, and long-term scalability.
  • Provide technical guidance to other engineers during implementation, ensuring high-quality, maintainable solutions.
  • Evaluate risk when implementing new features or refactoring, and propose safe rollout strategies.
  • Clean Architecture principles with clear separation of concerns
  • Microservices design patterns including service discovery, API gateways, and interservice communication
  • Multi-tenancy architecture with schema-based isolation
  • Event-driven architecture with message queues and async processing
  • Subprocess isolation patterns for credential management and security boundaries
  • Influence architectural direction across teams, helping bring clarity and structure to ambiguous problems.
  • Architect robust AI agent execution layers that ensure determinism, observability, and reliable stepwise execution.
  • Write comprehensive automated tests using pytest and Jest, including integration and behavior-driven tests.
  • Implement structured logging, correlation IDs, and observability patterns to ensure system clarity and operability.
  • Contribute to and improve CI/CD pipelines with automated testing, linting, and deployment workflows.
  • Set up effective monitoring and alerting for production systems.
  • Lead or support critical incident resolution with calm, context-driven decision-making.
  • Drive platform-wide improvements in performance, reliability, and technical quality.
  • Exercise independent judgment in methods, techniques, and evaluation criteria to ensure robust outcomes.
  • Instrument AI agent systems with monitoring, tracing, and guardrails to ensure safe and predictable behavior in production.
  • Document architectural decisions, engineering patterns, and approaches that become long-term references for the team.
  • Provide approach summaries and technical proposals before major implementations to ensure alignment with product and engineering partners.
  • Participate in planning and estimation, applying deep technical judgment and strong product awareness.
  • Mentor engineers, raise team capabilities, and guide others through complex engineering workflows.
  • Build relationships across engineering and product groups, influencing roadmaps and cross-team initiatives.
  • Communicate risks, challenges, and opportunities proactively and clearly to stakeholders.
  • Document and evangelize best practices for safe, reliable, and maintainable AI agent design.
  • 10+ years of professional software development experience, including significant experience owning and delivering large-scale technical systems.
  • You should bring the ability to design durable architectures, independently lead high-impact engineering efforts, and mentor other engineers while maintaining exceptional coding standards.
  • You should enjoy architecting clean, resilient services, solving complex systems problems, and shaping long-term technical direction for the areas you support.
Desired Qualifications
  • Production Kubernetes experience with Helm charts and orchestration
  • Experience with Databricks or similar cloud data platforms
  • LangChain/LangGraph production implementations
  • Model Context Protocol (MCP) integration
  • React micro-frontends with module federation
  • Dapr or similar service mesh frameworks
  • Multi-tenant SaaS application development
  • Certain positions are also eligible for variable pay; your recruiter will discuss the full compensation package details.

Dotmatics provides a cloud-based R&D software platform for life sciences, chemistry, biology, and materials research, unifying data management, workflow automation, and analytics. Its suite includes GraphPad Prism, SnapGene, and Geneious, plus Luma, a low-code platform for multimodal drug discovery, to capture, analyze, and share experimental data. The platform automates tasks such as instrument data ingestion, electronic lab notebooks, assay analysis, and dashboard reporting, harmonizing data across labs to boost collaboration and speed discovery. In 2025, Dotmatics was acquired by Siemens and integrated into Siemens Digital Industries Software, expanding Siemens' AI-driven product lifecycle capabilities in life sciences.

Company Size

501-1,000

Company Stage

Acquired

Total Funding

$5.9B

Headquarters

Boston, Massachusetts

Founded

2005

Simplify Jobs

Simplify's Take

What believers are saying

  • Siemens $5.1B acquisition in April 2025 boosts resources and distribution.
  • BioBright acquisition accelerates lab automation for future workflows.
  • FedRAMP authorization on April 30, 2025 unlocks U.S. federal contracts.

What critics are saying

  • Schrödinger erodes 30% faster molecule optimization, cutting Luma share in 12 months.
  • Benchling captures 25% ELN users via CRISPR UX, driving churn in 6 months.
  • AlphaFold 4 commoditizes BioGlyph, wiping 40% biologics ARR in 12 months.

What makes Dotmatics unique

  • Dotmatics unifies ELN, registration, inventory, and assays on single platform since 2005.
  • Luma Agent executes complex tasks via natural language with full audit trails.
  • Portfolio includes GraphPad Prism, Geneious, and BioGlyph for multimodal R&D.

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Benefits

Remote Work Options

Unlimited Paid Time Off

Flexible Work Hours

401(k) Retirement Plan

401(k) Company Match

Health Insurance

Health Savings Account/Flexible Spending Account

Dental Insurance

Vision Insurance

Paid Vacation

Paid Holidays

Sabbatical Leave

Hybrid Work Options

Stock Options

Company Equity

Wellness Program

Mental Health Support

Gym Membership

Phone/Internet Stipend

Home Office Stipend

Conference Attendance Budget

Professional Development Budget

Family Planning Benefits

Fertility Treatment Support

Adoption Assistance

Parental Leave

Parental Leave

Family Planning Benefits

Company News

Siemens Switzerland
Sep 17th, 2025
Siemens completes acquisition of Dotmatics

Siemens AG announced today that it has completed the acquisition of Dotmatics, a leading provider of Life Sciences R&D software headquartered in Boston and port

Securities and Exchange Commission
Jul 16th, 2025
SEC FORM D

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.The reader should not assume that the information is accurate and complete.

Securities and Exchange Commission
Jul 16th, 2025
SEC FORM D

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.The reader should not assume that the information is accurate and complete.

Insight Partners
Jul 15th, 2025
Dotmatics | Investment | Insight Partners

Dotmatics is a leader in R&D scientific software connecting science, data, and decision-making.

Business Wire
Jul 15th, 2025
Dotmatics Acquires BioBright to Accelerate Laboratory Data Automation for the Lab of the Future

Dotmatics acquires BioBright to accelerate laboratory data automation for the Lab of the Future

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