Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians.

Why? Protein dysfunctions directly cause many diseases, such as Alzheimer’s disease. Yet, proteins remain understudied because of technological hurdles.

How? To resolve these limitations, PTI will develop mass tags enabling a new framework for multiplexed protein analysis by mass spectrometry towards achieving 100-fold increase in throughput. Scientists at and collaborating with the institute will use these gains to directly investigate disease mechanisms and resolve problems that have proven intractable for decades. Our proof of principle technology and strategies are outlined at: parallelsq.org.

New career opportunities

Members of PTI will be supported with industry-level resources to lead research projects and disseminate their discoveries and innovations to the broader biomedical community through frequent publications, presentations, and submissions to public data portals.

Summary of Position

We are looking for an Immunopeptidomics Scientist who has done research in the field of mass spectrometry-based proteomics. This position will focus on using bulk and single-cell analysis to increase the throughput of HLA and/or MHC peptide identification. The idea candidate has an in-depth understanding of instrumentation in addition to sample processing and data analysis. In this role, the successful applicant will have the opportunity to work closely with co-founders and an interdisciplinary group of researchers to help achieve PTI’s milestones. In order to be seriously considered for this position, we require a cover letter as part of the candidate’s application.

Responsibilities:

Develop highly-sensitive immunopeptidomics workflows for data acquisition by LC-MS/MS pipelines.
Collaborate with biologists, chemists, research associates, computational scientists, and mass spectrometrists to leverage PTI’s multiplexing platform.
Collaborate with external labs as needed.
Mentor scientists and research associates. Prepare internal reports and manuscripts, and present results at internal or external scientific meetings as appropriate.
Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.
Other duties as assigned.

Qualifications:

Ph.D. degree in Immunology, Biochemistry, Molecular Biology, or a related field.
Experience in immunopeptidomics, in particular: optimization of protocols for extraction and isolation of immunopeptides from biological samples.
Excellent communication and interpersonal skills, record keeping ability, attention to detail.

Preferred Qualifications:

Experience with LC-MS/MS.
Experience with mass spectrometry proteomics.
Experience with bioinformatics tools and software used for mass spectrometry data analysis.
Experience using R, Python, or similar computational language/software.

We offer:

An opportunity to change the world and work with some of the smartest and the most talented experts from different fields.
Excellent medical, dental, and vision insurance with many $0 premium options for you and your family with several national and regional providers. Most employees have more than 20 plan options to choose from.
Company-paid group life, AD&D, long- and short-term disability insurance
15 days PTO + 10 sick days per year
18 company holidays + your birthday off
$5,000 per year educational reimbursement
Up to 16 weeks paid parental leave

We aim to help fill a structural gap in today’s R&D system. We enable fundamental research that requires unusual levels of scale and coordination yet is not rapidly monetizable by industry. We’re bringing together top talent from academia, industry, and startups to build a new model for innovative R&D. As an incubator within the Schmidt Futures Network, we identify high-impact scientific or technical research and development opportunities, ultimately defining and launching these projects as Focused Research Organizations.

We are an Equal Employment Opportunity employer that proudly pursues and hires a diverse workforce. We do not make hiring or employment decisions on the basis of race, color, religion or religious belief, ethnic or national origin, nationality, sex, gender, gender-identity, sexual orientation, disability, age, military or veteran status, or any other characteristic protected by applicable local, state, or federal law or company policy. We strive for a healthy and safe workplace and strictly prohibit harassment of any kind.

Immunopeptidomics Scientist

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