About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. As a Principal Research Associate, Histology and Imaging Core Lab, you will report to the Executive Director of Toxicology and Pathology. You are expected to have hands-on experience in basic digital imaging and image analysis using any of the proprietary software modules (E.g., Halo, Image J/FIJI, QUPATH, VisioPharm, Definiens).  Key responsibilities of the role include scanning histology slides; archiving of images; and analyzing and presenting data from histology scans. You should be familiar with digital whole slide scanners, data archiving and management. In addition, you are expected to have basic knowledge related to tissue trimming, processing, staining procedures, and day to day operations of a histology lab. Experience in molecular histology techniques (IHC/ISH staining) is also a bonus. You will work independently with minimal supervision and assist the Histology Core Manager to meet project goals.

What you’ll do

• Under the general direction of the Histology Core Manager and the ED of Pathology, you will provide image analysis (digital pathology) support to meet project and company goals. Core competencies include acquisition and analysis of histology images using slide scanners and morphometric analysis of histology data using software modules
• You are expected to have basic experience in tissue processing techniques, follow established protocols and focus on histological techniques including:

• Standard and special histochemical stains (H&E, PAS, Trichrome, etc)
• Manual and automated immunohistochemistry (IHC) and in situ hybridization
• Knowledge of histology core lab operations (equipment operations, maintenance, troubleshooting)
• Experience with tissue collection from laboratory animal studies

• You will work in a collaborative manner with the Histology Core Manager to maintain equipment, develop and qualify new, innovative staining techniques
• Effectively communicate and present learnings to a diverse audience. Train fellow scientists on the new digital pathology and workflow automation tools and write SOPs

What we’re looking for

• BS in Biology, Bioinformatics, or Statistics
• Strong skill set in digital imaging and image analysis
• Hands-on experience with imaging software modules
• Experience with routine histology stains and routine operations of a histology lab
• Ability to multi-task and work cross-functionally with team members and team environments
• Effective communicator both verbally and in writing
• Excellent organizational skills required to manage multiple studies at different phases in parallel and track work and projects to meet timeline demands
• Must be proficient with MS Office (Word, Excel, PowerPoint etc)

What will separate you from the crowd

• Bachelor’s with HT or HTL certification and 5 years of lab experience
• HT or HTL certification and/or basic knowledge in histology lab activities
• Experience with trimming and processing tissues samples for routine histology endpoints
• Knowledge of the design and conduct of laboratory animal studies.
• Demonstrated interpersonal skills to interact and work with internal project scientists, external contract labs and Study Directors
• Experience with special staining techniques (ISH/IHC)

What you should know

• The base pay range for this position at commencement of employment is expected to be between $98,000 and $118,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience