Scientist I @ Mammoth Biosciences

OPPORTUNITY

We are seeking a highly motivated and detail-oriented Scientist I to join our Analytical Development (AD)/Quality Control team at Mammoth Bioscience. The successful candidate will play a critical role in ensuring the quality and stability of cell and gene therapy products, including gRNA, mRNA, lipids, and LNP. This position requires a strong background in analytical techniques, excellent problem-solving skills, and the ability to work collaboratively in a fast-paced environment.

KEY RESPONSIBILITIES

Develop, optimize, and transfer analytical methods for QC testing
Perform routine and non-routine analytical testing of cell and gene therapy products for lot release, stability, and characterization
Serve as a Subject Matter Expert (SME) in multiple analytical techniques and provide technical troubleshooting support
Collaborate with cross-functional teams, including Process Development, groups under Discovery and Translational Research to support method development, transfer, characterization, comparability, and investigation projects
Analyze, track, and trend data to monitor analytical assays and ensure consistency in assay performance
Author and review Standard Operating Procedures (SOPs) and technical reports and assist in the preparation of Chemistry, Manufacturing, and Controls (CMC) regulatory submissions
Maintain detailed documentation of experiments and test results in an Electronic Laboratory Notebook (ELN) system
Adapt to a fast-paced, dynamic research environment, demonstrating flexibility and strong problem-solving skills

REQUIRED QUALIFICATIONS

Degree in relevant discipline (biochemistry, chemistry, bioengineering or related fields)
PhD, or Master’s degree + 3 years minimum experience, or Bachelor’s degree with 5 years minimum experience
Strong expertise in analytical techniques such as HPLC (IP-RP, SEC, IEX), capillary gel electrophoresis, fluorescence-based RNA quantitation, qPCR, ELISA, UV spectrophotometry, DLS, MALS, Mass Spectrometry with focus on RNAs, lipids and lipid nanoparticles (LNPs)
Proficiency in data analysis, statistical analysis, and trend analysis
Excellent written and verbal communication skills
Ability to work collaboratively with cross-functional teams
Strong problem-solving and technical troubleshooting skills
Proficiency with software tools such as JMP, GraphPad Prism, LIMS, and ELN systems

PREFERRED QUALIFICATIONS

Experience in developing, qualifying, and testing analytical methods in both GMP and non-GMP settings, ideally within the biotech or pharmaceutical industry
Analytical CMC development, method transfer, stability programs and CRO/CDMO management is highly desirable
CMC project management experience will be a plus
Excellent organizational skills towards multitasking in an extremely fast-paced environment with changing priorities

BENEFITS

Company-paid health/vision/dental benefits
Unlimited vacation and generous sick time
Company-sponsored meals and snacks
Wellness, caregiver and ergonomics benefits
401(k) with company matching

Base Salary Range: $ 124,000 - $142,170

Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity.

COMPANY

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.

Scientist I

Analytical Development / Quality Control

Mammoth Biosciences

Compensation Overview

KEY RESPONSIBILITIES

REQUIRED QUALIFICATIONS

PREFERRED QUALIFICATIONS

BENEFITS

6 month growth

1 year growth

2 year growth

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