Full-Time
Computational Chemist I
Posted on 2/5/2024
1910 Genetics
11-50 employees
AI-driven drug discovery and development
Junior, Mid
Cambridge, MA, USA
- Ph.D. in chemistry
- 2+ years of postdoctoral or industrial experience
- Proficiency with the Microsoft Office Suite (Excel, Word, PowerPoint, Teams), G-Suite
- Roll up your sleeves as an Individual Contributor (IC) and play an important role in our mission to use AI/ML to develop drugs against historically difficult disease targets
- Learn Medicinal Chemistry, Biochemistry and biophysics, AI/ML applied to drug discovery, Existing tools, systems, and processes that currently support the 1910 Genetics team
- Own computational chemistry programs across therapeutic modalities, disease targets, and indications
- Implement computational chemistry toolkits (e.g., MOE, CCDC, Cresset) to run virtual screening campaigns to rapidly identify drug candidates for further development while proactively seeking and incorporating input from Medicinal Chemistry
- Collaborate with the Biology and Medicinal Chemistry teams by providing key computational chemistry insights to aid in the Hit-to-Lead and Lead Optimization phases of drug discovery operations
- Collaborate with the ML Engineering and AI Research team by providing key computational chemistry insights to aid in the development of AI/ML models for drug discovery as well as the incorporation of those models into drug discovery operations
- Teach key computational chemistry principles to cross-disciplinary colleagues from Medicinal Chemistry, AI Research, Machine Learning Engineering, Cell Biology, and Pharmacology
- Improve the existing process for progressing from computational hit to experimental hit to lead to drug candidate
- Propose a few hundred virtual hits to the Medicinal Chemists for synthesis
- Progress a virtual hit to a biochemical/cellular hit, Co-author provisional patents on hit scaffolds
- Validate a cellular hit in a clinically relevant animal model of disease, Update provisional patents with the animal model data
- Nominate a lead candidate for progression into IND-enabling studies
At 1910 Genetics, they employ a pioneering combination of AI, computation, and biological automation to enhance the drug development process, specializing in both small molecule and protein therapeutics across various therapeutic areas. Their ability to streamline the entire early drug discovery process with platforms like ELVIS™ and ROSALYND™ positions them as a leader in accelerating therapeutic innovations. This focus not only promotes an advanced technological environment but also cultivates a culture of cutting-edge research and development, making it an excellent workplace for those passionate about transforming healthcare through science.
Company Stage
Series A
Total Funding
$34.7M
Headquarters
Boston, Massachusetts
Founded
2018
6 month growth
↑ 8%1 year growth
↓ -3%2 year growth
↑ 4%Benefits
Extremely generous equity package
Competitive salary
Healthcare benefits
Generous vacation and parental leave
Super cool team building activities
Flexible work schedule