Principal Scientist

Company Background

Opportunity

We are in the discovery stage and will invest heavily in its emerging platform for oligonucleotide delivery. Our disease focus offers strong translatability from animal models to humans, which provides a potentially rapid and efficient path to the clinic. Given our recent funding and commitment to building a first-in-class platform with clear therapeutic targets and indications, we are recruiting a Principal Scientist, Analytical Chemistry. This individual will be responsible for developing analytical methods and characterizing our oligonucleotide conjugates for our targeted delivery platform.

The Position

The Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross-functional teams to advance oligonucleotide therapeutic programs. This individual will help define and execute the strategy to analyze oligonucleotides and conjugates in an efficient and timely manner. As a lab-based role, this person will assist in the implementation and use of scientific and analytical equipment to yield high-quality oligonucleotide and oligonucleotide-conjugate materials.

Specific responsibilities for the Principal Scientist, Analytical Chemistry include:

• Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform
• Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio)analytical assays, etc.)
• Develop and implement analytical methods (e.g., MS) to determine drug-to-conjugate ratios of antibody-oligonucleotide conjugates
• Develop and implement analytical methods to determine in vitro stability (e.g., serum stability) of oligonucleotides and conjugates
• In conjunction with the biology group, assist in development and implementation of analytical methods to determine pharmacokinetics and distribution of oligonucleotides and conjugates in vivo
• Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide-oligonucleotide conjugates
• Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates

The Principal Scientist, Analytical Chemistry should be a doer with the ability to characterize high-quality conjugate materials efficiently and effectively, while contributing to the interpretation of complex scientific data. This person should have direct experience working on oligonucleotide platforms with a significant background in chemistry or a related discipline. This person must demonstrate strong technical skills, with a robust attention to detail to ensure rigorous and demonstrable results.

Key qualifications for the Principal Scientist, Analytical Chemistry include:

• PhD. in chemistry or related discipline with 6+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+ years
• Ideal candidate will have experience analyzing peptide-, protein-, or antibody-oligonucleotide conjugates, effectively operating in a cross-functional, collaborative environment
• Adept in state-of-the-art analytical methods (SEC, IEX, RP-HPLC, MS, etc.) to characterize oligonucleotide conjugates
• Experience in (bio)analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus
• While demonstrating creativity to contribute to the development of novel delivery systems, this individual must also be process- and detail-oriented to ensure proper release of high-quality oligonucleotide material for in vivo testing
• Imperative that this individual be an effective communicator and proven team-player, with the ability to operate independently in a laboratory setting

At a personal level, we are seeking an individual who is highly collaborative, intellectually curious, driven, trustworthy, humble, and who brings an adaptable and flexible working style. The Principal Scientist, Analytical Chemistry must be highly organized, thoughtful, and bring sound judgement and technical decision-making abilities. The company is creating a culture of highly engaged colleagues who put the team and the science above the self and operate with a sense of urgency. As such, the Principal Scientist, Analytical Chemistry should be highly nuanced in terms of their interpersonal style and able to lead and work effectively within a highly collaborative, entrepreneurial, and fast-paced start-up environment.

From an educational perspective, we are seeking an individual with a Ph.D. and/or BS/MS in a relevant discipline such as chemistry or analytical sciences. It is understood that education, while an important index of achievement, orientation, and intellectual capacity, will not constitute the primary variable in this decision process. Personal characteristics, leadership abilities, technical fluency, creativity, work ethic, behavioral flexibility, and demonstrated accomplishments will serve as key components in the evaluation of candidates. This person will be based on-site at the company’s headquarters in Cambridge, MA.

Salary base range 160000 - 190000 USD