Full-Time

Associate Scientist I

Conjugation Development

Updated on 4/25/2024

Vaxcyte

Vaxcyte

201-500 employees

Develops broad-spectrum bacterial infection vaccines

Biotechnology

Entry

San Carlos, CA, USA

Required Skills
Mergers & Acquisitions (M&A)
Requirements
  • BS or MS Degree in Chemistry, Biochemistry or related discipline with 0-2 years of industrial experience.
  • Experience in setting up and carrying out chemical reactions.
  • Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, size-exclusion chromatography, and tangential flow filtration (TFF).
  • Hands-on experience with analytical methods including reversed-phase HPLC, colorimetric assays, size-exclusion chromatography (SEC), and SDS-PAGE for characterization of reaction products.
  • Direct experience operating Agilent HPLC using OpenLab/Chemstation software and/or Waters UPLC and Empower software for data acquisition and analysis is a plus.
  • Highly organized, strong attention to details and excellent record-keeping/documentation abilities.
  • Critical thinking and ability to analyze data.
  • Eager and able to learn and understand new concepts.
  • Strong interpersonal skills and ability to communicate effectively with team members.
  • Ability to work under supervision and collaborate effectively with team members.
  • Committed to upholding high standards of integrity, professionalism, and safety in all aspects of work.
Responsibilities
  • Optimize and troubleshoot multi-step synthesis of protein-polysaccharide conjugates.
  • Analyze conjugates with several methods including colorimetric assays and multiple HPLC assays.
  • Purify conjugates using a variety of methods including size-exclusion chromatography and tangential flow filtration (TFF).
  • Contribute to the development and execution of Design of Experiment (DoE) models for process development.
  • Support the development work toward a process characterization of conjugate vaccine.
  • Complete any assigned tasks in high quality and in a timely manner.
  • Maintain good documentation practices for recording experimental plans and results in electronic lab notebook and associated reports.
  • Assist in troubleshooting of instrumentation and test methods, including the ordering of supplies and maintenance of equipment.
  • Participate in group meetings, present results of work, interpret data, and report results in an accurate manner.
  • Work within a team environment and provide support to further team objectives.

Vaxcyte is centered on creating advanced vaccines such as VAX-24, a sophisticated 24-valent pneumococcal conjugate vaccine, by utilizing cutting-edge chemistry and the XpressCF™ cell-free protein synthesis platform. The company prioritizes developing high-fidelity, broad-spectrum vaccines to combat bacterial infections, continuously expanding its product pipeline with innovations like VAX-31 for various bacterial threats.

Company Stage

IPO

Total Funding

$2.3B

Headquarters

San Carlos, California

Founded

2013

Growth & Insights
Headcount

6 month growth

33%

1 year growth

65%

2 year growth

165%