About BridgeBio Oncology Therapeutics

BridgeBio Oncology Therapeutics (“BBOT”) is a private biotech company dedicated to developing innovative new therapeutics to address dire unmet needs in oncology. Founded on a commitment to patients, scientific excellence, and operational agility, we understand that every minute counts in our efforts to develop new therapies to transform the lives of people living with cancer. Driven by a team of experienced scientists, clinicians, and industry experts, our team utilizes cutting-edge structure-based drug discovery techniques to target some of oncology’s most challenging and validated molecular targets, including KRAS and PI3Kα. BBOT has a pipeline of several promising differentiated drug candidates and strong investor support, the combination of which positions us to deliver meaningful benefit to patients. Our offices and laboratory are in South San Francisco, though our colleagues and collaborators span the country and globe.

To learn more, visit us at bridgebiooncology.com

Who You Are

• This is an exciting opportunity for a highly motivated Research Associate III/Sr. Research Associate to contribute to drug discovery activities for the development of novel small molecule cancer therapeutics as part of our cancer biology discovery team.
  The successful candidate will collaborate with team members to conduct a variety of in vivo and ex vivo oncology research techniques including: biochemistry, molecular, cellular biology, and rodent oncology models.
  This position also requires some lab management and operational tasks. We are looking for a talented and enthusiastic individual, who thrives in a collaborative, fast-paced and growing environment to join our team.

Responsibilities

• Execution of in vivo (tumor cell inoculations, dosing (po, sc, ip, iv), and blood sampling) and ex vivo pharmacology experiments (target and mechanism engagement) to assess the inhibition or activation of novel targets in the oncology setting
• Assist in the planning and design of model development, PK/PD, tolerability, and efficacy studies using mostly (but not limited to) small molecule therapeutics
• Graph, interpret, and communicate experimental data
• Maintain records in written and electronic laboratory notebooks
• Manage lab inventory and equipment
• Understand and implement applicable regulations around animal care/safety/handling

Education, Experience & Skills Requirements

• Highly motivated, committed individual with good organizational skills
• BS/MS in a biology-related discipline
• BS and >3 years, or MS and >2 year hands-on experience in a cell/molecular biology laboratory (oncology setting highly preferred.
• Experience with oncology in vivo models: xenografts and syngeneic, tumor measurements, ex-vivo pharmacodynamics
• Experience with mammalian cell culture, test article formulation, protein expression quantification (ELISA, MSD), qPCR, and western blot/immunoprecipitation
• Experience with analyzing and presenting study results
• Industry experience preferred
• Strong written and oral communication skills

What We Offer

• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak.
• A place where you own the vision – both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game.
• Robust and market-competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Commitment to Diversity, Equity & Inclusion