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Associate Director/Director
Confirmed live in the last 24 hours
San Francisco, CA, USA • Remote • Sorrento Valley, San Diego, CA, USA
Experience Level
Desired Skills
  • Ph.D. with 7+ years or BS/MS with 15+ years of relevant industry experience in the field of ADME/PK
  • Expertise in a key DMPK subdiscipline, such as, drug metabolism, enzymology, preclinical PK/PD, modeling-simulation and DDI risk assessment, with a working knowledge in other areas
  • Understanding of the role of physicochemical properties, drug metabolizing enzyme, transporters, pharmacokinetics, mechanistic biotransformation and analytical sciences in drug discovery
  • Demonstrated capability to mentor junior scientists in a matrix environment, build strong relationships cross functionally and with academic and CRO partners
  • Demonstrated project team experience and ability to work effectively in a matrixed, global environment as part of a multidisciplinary team
  • Strong problem solver who is highly organized with the ability to thrive in an environment with rapidly changing priorities
  • Strong interpersonal skills with an ability to develop solid, long term relationships and the ability to influence others, and adept at working across multiple cross-functional areas
  • Excellent oral and written communication skills
  • DMPK support of small molecule drug discovery programs through use of customized in vitro assays, involving use of established and novel sub-cellular and cell-based systems (e.g. microsomes, hepatocytes, Caco-2, MDCK-MDR cell lines, long term co-culture models, organoids) and in vivo ADME experiments, with analysis primarily through LC/MS detection
  • Implement in house strategies for metabolic profiling/structure elucidation, DDI, understanding metabolic liabilities to support discovery and development projects, including execute workflows designed to inform a Metabolites in Safety Testing (MIST) strategy and toxicology/TK assessments
  • Design and coordinate studies at CRO's. Participate in the management of CROs in the conduct of in vitro/in vivo ADME studies including, and up till, 14C-mass balance and QWBA studies
  • Prepare preclinical DMPK reports according to regulatory standards. When needed, coauthor (under supervision) high quality regulatory documents like INDs, DSURs etc
  • Play a key role in the selection of lead compounds and nomination of development candidates, collaborating closely with medicinal chemistry, pharmacology, toxicology and clinical pharmacology teams
  • Demonstrates technical knowledge in high resolution LC-MS/MS, with breadth of ADME analytical instrumentation experience

51-200 employees

Technology-enabled pharmaceutical company
Company Overview
Atomwise's mission is to make better medicines faster. They look to leverage the power of AI to revolutionize small molecule drug discovery. The Atomwise team invented the use of deep learning for structure-based drug design.
  • Medical, dental, & vision
  • FSA
  • 401k
  • Parental leave
  • Commuter benefits
  • Professional development
Company Core Values
  • Collaborative
  • Academic environment
  • Data driven
  • Innovative
  • Growth
  • Inclusive
  • Family-oriented
  • Professional & supportive