WHAT YOU WILL DO:

• Support the preclinical In Vivo Translation team utilizing tumor xenograft and syngeneic mouse models for discovery and IND-enabling studies for CAR-T adoptive cell therapy.
• Role involves design and execution of in vivo studies, as well as model development to support mechanistic and discovery science as well as pharmacology efforts to advance projects as required.
• Execute hands-on responsibilities including, but not limited to animal handling and restraint, administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection. In addition, providing daily care and monitoring of mice, including health checks and documentation, will also be required.
• Follow all institutional, local, and federal regulations regarding animal care and use. Adhere to safety protocols and maintain a clean and organized work environment. Maintain detailed and accurate records of all procedures and animal health status; investigate adverse study events. Meticulous electronic lab notebook documentation.
• With minimal guidance, collect, analyze, interpret, and present data within the Pre-clinical Pharmacology group and across functional areas within the company.
• Desgin and perform rodent dosing studies, in vivo candidate selection studies, blood and tissue sampling, flow-cytometry based PK and immune cell phenotyping analysis, surgeries and isolation of tumor infiltrating CAR-T cells for mechanism of action as required.
• Execute ex vivo techniques such as tissue dissociation, flow cytometry, Luminex/ELISA is highly preferred.
• Communicate experimental plans and results to the leadership team. Support product development and regulatory filings for pivotal clinical studies.

WHO YOU ARE:

• Masters with 5+ years experience, or Bachelor with 7+ years experience in a biotechnology/pharmaceutical company.
• Strong background in tumor biology, immunology, and in vivo tumor model development including human xenograft models and development of novel models to elucidate and characterize drug mechanisms of action. 
• Extensive hands-on experience with all aspects of running tumor models, including experience working with immune-oncology antibodies, small molecules, or cancer adoptive cell therapy is highly desired.
• Experience with aseptic cell culture of mammalian cell lines with additional weight given for CAR-T cells.
• Extensive experience in establishing mouse tumor models in immune competent and compromised animals.
• Proficiency in drug administration (SQ, IP, IV, and PO), blood collection routes (Sub-M and others) and full body necropsy. 
• Experience in diverse ex-vivo assays including flow-cytometry and tissue collection and downstream processing including for gene-expression and/or protein assays (luminex, ELISA).
• Software experience in Excel, Google suite, Prism, Powerpoint, electronic lab notebooks, and in vivo data management platforms.
• Demonstrated ability to work collaboratively in a cross-functional environment.
• Ability to follow instructions and work independently and to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines.
• Must have excellent troubleshooting, organization, and planning skills, and the ability to work under timeline in a fast-paced environment.
• Excellent written and oral communication skills to effectively share scientific findings.
• Excellent documentation skills including maintenance of daily records using Electronic Lab Notebooks and generation/maintenance of SOPs.