Principal Scientist
LNP Development
Updated on 3/28/2024
Beam Therapeutics

201-500 employees

Pioneering precision genetic medicines through CRISPR base editing
Company Overview
Beam Therapeutics, established in 2018, is a pioneer in the field of genetic medicine, utilizing CRISPR base editing to create precise, permanent alterations to single bases in DNA and RNA without breaking the strands. The company's culture is characterized by a community of fearless innovators, rigorous and honest research, open-mindedness, and commitment to each other. Their competitive advantage lies in their unique delivery strategy, which includes a range of clinically validated technologies such as electroporation, nonviral, and viral delivery modalities, positioning them as a leader in the genetic medicine industry.

Company Stage


Total Funding





Cambridge, Massachusetts

Growth & Insights

6 month growth


1 year growth


2 year growth

Cambridge, MA, USA
Experience Level
Desired Skills
Lab & Research
Life Sciences
  • PhD or MS in Pharmaceutical Sciences, Chemical engineering, Bioengineering or related field with of drug product and CMC development experience (PhD 6-8 years or MS 10-12 years).
  • Deep understanding of late stage product development activities. Product development experience especially in nucleic acids and drug delivery is preferred.
  • Comprehensive knowledge and understanding of solubility, phase-separation, colloidal stability, electrostatic and hydrophobic interactions; at a level that enables hypothesizing options for rational design/selection of excipients and formulation conditions (e.g. pH, ionic strength) to achieve directed self-assembly in complex mixtures.
  • Familiarity with ultrafiltration and aseptic unit operations for sterile drug product manufacture.
  • Knowledge of statistical techniques and concepts (regression, properties of distributions, statistical tests, and proper usage, etc.). Experience using statistical computer languages (R, Python, SQL, etc.) to manipulate data and draw insights from large data sets.
  • Excellent computational, written, and verbal communication skills, strong organizational abilities, and an ability to work with a diverse group of scientists and engineers.
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change.
  • Uses knowledge and expertise of statistics to collaborate with scientists in application of statistics to Drug Product Development: Quality by Design, formulation development and optimization, process design and optimization, experimental manufacturing campaigns, determining manufacturing design spaces, validation, experimental and registrational stability studies, probabilistic assessment of risk for critical quality attributes.
  • Design and execute experiments to enable a robust formulation and reproducible process for manufacture of clinical trial materials.
  • Contributes to the Chemistry, Manufacturing and Controls (CMC) strategy. Engages in scientific and technical discussions with multi-disciplinary team members to move forward with speed and accountability.
  • Leads technology transfer projects, including the establishment of the process/parameters for each unit operation of the process, and up until the completion of process performance qualification and subsequent CMC filing activities.
  • Generate data and knowledge for regulatory filings through planning and execution of experimental plans with minimal supervision, within project timelines.
  • Develops and maintains effective working relationships with other division groups in support of technology transfer, validation, and product development activities.