Job Description Summary
The Department of Pathology and Laboratory Medicine at the Medical University of South Carolina (MUSC) invites applications for a postdoctoral researcher position in Alzheimer’s disease (AD) research. We are seeking a highly motivated and talented research scholar to study the role of cellular senescence in brain aging and AD pathogenesis. A growing body of evidence has demonstrated the implications of senescent cells in AD, and a set of senolytic drugs are being tested
in clinical trials for AD treatment (https://pmc.ncbi.nlm.nih.gov/articles/PMC10168460/). However, the precise cellular and molecular mechanisms by which age associated accumulation of senescent cells in the brain affect AD pathogenesis and progression have yet to be determined. The successful candidate will utilize an array of state-of-the-art technologies and systems biology approach, including cellular & molecular biology techniques, single-cell RNA sequencing, spatial proteomics, RNAscope, neuropathology, supper-resolution confocal microscopy, and AD animal models, to delineate how senescent cells modulate neuroinflammation, AD pathology, and cognitive function in preclinical AD animal models.
Entity
Medical University of South Carolina (MUSC - Univ)
Worker Type
Employee
Worker Sub-Type
Regular
Cost Center
CC001002 COM PATH Basic Research CC
Pay Rate Type
Hourly
Pay Grade
University-00
Pay Range
0.00 - 0.00 - 0.000
Scheduled Weekly Hours
40
Work Shift
Job Description
Candidates should have a recent Ph.D. in neurobiology, molecular cell biology,neuroscience, or other related fields.Interested applicants should send your currentCV, a cover letter describing your research interests/previous experience/future career goals, and the contact information for three references to Dr. Gavin Wang at [email protected].Competitive salary and benefits will be commensurate with qualifications and experience.Previous experience with ADtransgenic mouse models, snRNA-seq,spatial proteomics,and confocal microscopy is highly preferred.
30% - In consultation with the PI, design and execute experiments to advance independent research projects. S/he will be responsible for planning experiments, developingnew assays and experimental modelsas needed, trouble shooting, data analysis and interpretation, and being able to incorporate the results into manuscripts and sections of grant proposals.
25% - Perform specific assays including histological procedures, quantitative RT-PCR, immunoblotting, immunofluorescence, confocal microscopy, and flow cytometry assays.
30% - Conduct standard animal experiments, including the handle of transgenic mice, mouse intraperitoneal and tail vein injections, rodent general surgeries (specific surgical procedures can be learned and trained as needed), collecting animal brain tissues,IHC, and data analysis.
10% - Assist the PI in training and supervising graduate students, technicians, research assistants and junior lab members.
5% - Attend seminars, career development activities locally and nationally at conferences, submit abstracts and present data at local, national & international meetings, and if applicable write postdoctoral fellowship applications and grant proposals.
Minimum Experience and Training Requirements
Candidates should have a Ph.D.in neuroscience, molecular cell biology, cellular neurobiology, or any otherrelated fields.
Preferred Experience & Additional Skills
Expert-level intellectual input to the research objectives and data interpretation of the PI’s projects.
Ability to work independently in experimental design and project execution.
Good oral and written communication skills.
Ability to train and supervise technicians and graduate students.
Additional Job Description
Physical Requirements: (Note: The following descriptions are applicable to this section: Continuous - 6-8 hours per shift; Frequent - 2-6 hours per shift; Infrequent - 0-2 hours per shift) Ability to perform job functions in an upright position. (Continuous) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb stairs. (Infrequent) Ability to work indoors. (Continuous) Ability to work in all cold temperature extremes, i.e. spot coolers. (Frequent) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to perform 'pinching' operations. (Continuous) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Continuous) Ability to fully use both legs. (Continuous) Ability to reach in all directions. (Continuous) Possess good finger dexterity. (Continuous) Ability to maintain tactile sensory functions. (Continuous) Ability to maintain good olfactory sensory function. (Continuous) Ability to lift and carry 15 lbs., unassisted. (Frequent) Ability to lift objects, up to 15 lbs., from floor level to height of 72 inches, unassisted. (Frequent) Ability to lower objects, up to 15 lbs., from height of 72 inches to floor level, unassisted. (Frequent) Ability to push/pull objects, up to 15 lbs., unassisted. (Infrequent) Ability to lift and carry objects up to 15 lbs. a distance of five (5) floors and to outlying buildings. (Frequent) Ability to maintain 20/40 vision, corrected. (Continuous) Ability to see and recognize objects close at hand. (Continuous) Ability to see and recognize objects at a distance. (Continuous) Ability to match or discriminate between colors. (Continuous) Ability to determine distance/relationship between objects; depth perception. (Continuous) Good peripheral vision capabilities. (Continuous) Ability to maintain hearing acuity, with correction. (Continuous) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to be qualified physically (by medical personnel) for respirator use, initially and annually. Ability to work alone in isolated areas, such as darkrooms. (Frequent) Additional New Requirements: Ability to obtain and maintain a valid drivers license. Computer literacy. Ability to work rotating shifts as required. Ability to work overtime as required. Ability to learn and use new processes, tools and equipment as required.
If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees
