Senior Director
Preclinical Programs, Heme a
Confirmed live in the last 24 hours

201-500 employees

Develops gene-editing tools for treating genetic diseases
Company Overview
Metagenomi, a leader in the gene-editing industry, is distinguished by its metagenomics-powered toolbox, enabling the development of potentially curative therapeutics for genetic diseases. The company's unique approach harnesses the power of metagenomics, studying genomes from uncultivated organisms, to discover and develop a suite of novel gene-editing tools. This approach allows Metagenomi to potentially make any desired therapeutic gene edit, anywhere in the human genome, setting it apart from competitors in the field.

Company Stage

Series B

Total Funding





Emeryville, California

Growth & Insights

6 month growth


1 year growth


2 year growth

Oakland, CA, USA
Experience Level
Biology & Biotech
  • Ph.D. in cell/ molecular biology/pharmacology
  • Exceptional leadership skills and at least ten years of experience managing senior-level scientists
  • Experience in rare inherited diseases with a focus on liver/ metabolic diseases including Hemophilia or other non-malignant hematological disorders
  • Demonstrated experience in drug discovery in the gene editing or gene therapy space
  • Experience in designing IND enabling studies including Tox and pharmacology studies
  • Successful experience writing/reviewing regulatory sections of IND
  • In-depth experience managing CROs to achieve nonclinical milestones on time and within budget
  • Comprehensive knowledge of the drug development process, including cross-functional integration from animal preclinical POC through Phase I
  • Experience in pharmacokinetics, toxicology, and animal pharmacology/monitoring animal studies
  • Experience leading and managing partnerships with biopharma
  • A transparent, flexible, can-do approach to address issues innovatively and proactively to promote teamwork and a pleasant work environment
  • Outstanding influencing, oral, and written communication skills
  • We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease
  • We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!
  • Reporting to the SVP Preclinical, lead the Hemophilia A gene editing program to a successful IND application
  • Partner with CMC, QC, BD, and the in vivo models team to design and execute IND-enabling studies to meet all regulatory requirements
  • Lead interactions with regulatory agencies to support IND study design
  • Successfully manage and scale a team of talented scientists and research associates to ensure timely execution and communication of research results with high-quality standards, enabling clear go-no/go decisions and timelines
  • Collaborate with the Chief Medical Officer to understand and plan for clinical translation and establish pre-clinical criteria for development candidate selection
  • Present progress updates to key decision-makers, including the executive team, partners, research, and management teams
  • Establish scientific standards and set strategic direction and priorities for gene editing strategies
  • Collaborate closely with Discovery and Protein Engineering groups to leverage advances in the gene editing platform for future therapeutics
  • Provide scientific leadership by proactively advising, sharing knowledge and expert opinions across functions and with senior management
  • Work with cross-functional leads to create and execute research strategies
  • Anticipate scientific barriers and proactively develops strategies to ensure the successful selection of development candidates
  • Oversee the development and execution of assays and studies (efficacy and mechanism of action) to enable the in vivo gene delivery platform and support drug candidate nomination and selection
  • Apply experience and expertise in preclinical development of gene editing drugs to guide in vivo study design
Desired Qualifications
  • We offer competitive compensation including a market-benchmarked salary, annual target potential, pre-IPO equity, and a comprehensive benefits plan, including 401(k) with company matching, a retirement safe harbor plan, and other perks