Myeloma Postdoctoral Associate

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CORE JOB SUMMARY
The Post Doctoral Associate performs scientific research and studies under the supervision of managing staff. Moreover, the Post Doctoral Associate promotes institutional recognition through literal contributions to the scientific community.

CORE JOB FUNCTIONS
1. Conducts research on specific areas of study as assigned.
2. Prepares research reports and technical papers for publishing.
3. Investigates the feasibility of applying a wide variety of scientific principles and theories.
4. Maintains substantial knowledge of state-of-the-art principles and theories.
5. Develops advanced analytical models and systems and provides solutions and analyses to support strategic and tactical decisions.
6. Adheres to University and unit-level policies and procedures and safeguards University assets.

This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.

CORE QUALIFICATIONS
Education:
Doctorate degree in relevant field required

Experience:
No previous experience required

Certification and Licensing:
Refer to department description for applicable certification requirements

Knowledge, Skills and Abilities:

• Learning Agility: Ability to learn new procedures, technologies, and protocols, and adapt to changing priorities and work demands.
• Teamwork: Ability to work collaboratively with others and contribute to a team environment.
• Technical Proficiency: Skilled in using office software, technology, and relevant computer applications.
• Communication: Strong and clear written and verbal communication skills for interacting with colleagues and stakeholders.

This is a core job profile description and is not reflective of all duties that may be assigned to a specific position in each individual department. The above statements are intended to describe the general nature and primary responsibilities of this core job profile. Specific duties and tasks may vary based upon departmental needs. Other duties may be assigned to the above consistent with the knowledge, skills, and abilities required for the job.

Department Specific Functions

This post-doc will work in the laboratory of Dr. Brian Walker on the Genomics and Epigenomics of Multiple Myeloma, which is embedded in Sylvester’s Myeloma Institute (Director Dr  C. Ola Landgren) which is a world-class Center of Excellence for clinical care and cutting-edge research focused on multiple myeloma and its precursor conditions. Sylvester’s Myeloma Institute is part of Sylvester Comprehensive Cancer Center (Director Dr. Stephen Nimer), the only NCI designated cancer center in Southern Florida.

The successful applicant will analyze complex genomic datasets originating from patient samples, patient-derived xenografts, and cell lines. We use large genomic datasets to identify the mechanisms of disease progression, treatment resistance, and biological processes. This analysis includes identification of mutations, copy number changes, and structural variants as well as DNA methylation profiles and chromatin states. We use both short-read and long-read data as well as proximity ligation data to inform DNA topology and super-enhancer interactions across the genome.

Techniques to be used include: analysis of whole genome sequencing, DNA methylation, Micro-C, ChIP-seq, RNA-seq data from patient samples and myeloma cell lines.

Preferred: experience with NGS analysis, R/Python, other computational languages, bioinformatic analysis.

References:

Mikulasova A, Morgan GJ, Walker BA (2022) Chromosomal abnormalities in multiple myeloma. Nature Reviews Disease Primers 8:42. PMID: 35710551

Mikulasova A, Kent D, Trevisan-Herraz M, Karataraki N, Fung KFM, Ashby C, Cieslak A, Yaccoby S, van Rhee F, Zangari M, Thanendrarajan S, Schinke C, Morgan GJ, Asnafi V, Spicuglia S, Brackley CA, Corcoran A, Hambleton S, Walker BA, Rico D, Russell LJ (2021) Epigenomic translocation of H3K4me3 broad domains following super-enhancer hijacking. Genome Research. doi:10.1101/gr.276042.121. PMID:34933939.

Rico D, Kent D, Mikulasova A, Karataraki N, Walker BA, Javierre BM, Russell LJ, Brackley CA (2022) High-resolution simulations of chromatin folding at genomic rearrangements in malignant B-cells provide mechanistic insights on proto-oncogene deregulation. Genome Research 23:1355-1366. PMID: 35863900

Ashby C, Bauer MA, Boyle EM, Mikulasova A, Wardell C, Williams L, Siegel A, Braustein M, Blaney P, Kaminetsky D, Keats J, Maura F, Landgren O, Walker BA, Davies FE, Morgan GJ (2022) Structural variants shape the genomic landscape and clinical outcome of multiple myeloma. Blood Cancer Journal.12:85. PMID:35637217

Department Specific Qualifications                                                                                     

Education:

PhD computer science or biological science with an emphasis on genomic data analysis.

Experience:

Genomic data analysis, epigenomic data analysis, chromatin states, expression data.

The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

The University of Miami is an Equal Opportunity Employer. Applicants and employees are protected from discrimination based on certain categories protected by Federal law.

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