Full-Time

Principal Software Engineer

Backend Engineering

Posted on 9/30/2025

Red Cell Partners

Red Cell Partners

51-200 employees

Incubator for tech-based healthcare and security

Compensation Overview

$200k - $300k/yr

+ Equity Incentives

Seattle, WA, USA + 1 more

More locations: McLean, VA, USA

Hybrid

Category
Software Engineering (1)
Required Skills
gRPC
Kubernetes
Microsoft Azure
Python
Docker
TypeScript
AWS
Go
Terraform
Google Cloud Platform
Requirements
  • 10-15+ years of experience designing, building, and operating large-scale, distributed, cloud-native platforms
  • Proven experience as a Principal/Staff Engineer or Senior Architect, setting technical direction and making high-impact architectural decisions across multiple teams
  • Proficiency in programming languages such as Python, Go, or Typescript, with a strong ability to write clean, maintainable code
  • Expertise in modern cloud architecture (GCP, AWS, Azure), containerization (Docker, Kubernetes), and IaC (Terraform)
  • Deep knowledge of scalable architectures, API design (REST, gRPC), and event-driven systems
  • A systems-thinking approach to problem-solving and making strategic trade-offs (performance, cost, security)
  • Exceptional communication skills with a proven ability to drive technical alignment
  • Significant plus: Experience with infrastructure for ML Ops (model training, deployment, monitoring)
  • BS/MS in Computer Science or a related field, or equivalent experience
Responsibilities
  • Define and own the long-term technical vision and architectural roadmap, aligning it with business and product strategy
  • Drive the selection and governance of foundational technologies, frameworks, and architectural patterns
  • Future-proof the platform by anticipating technical challenges and industry trends
  • Establish and enforce engineering-wide best practices for architecture, code, and design
  • Drive initiatives to reduce technical debt and enhance platform scalability, security, performance, and observability
  • Serve as the decision-maker on critical system designs, ensuring architectural cohesion across teams
  • Mentor senior engineers and tech leads, elevating the team's architectural and problem-solving skills
  • Lead hands-on by prototyping solutions and solving the most complex technical challenges
  • Cultivate a culture of technical excellence and innovation across the engineering organization
  • Translate ambiguous business needs into clear technical strategies by partnering with executive, product, and enterprise leaders
  • Communicate complex architectural decisions to all stakeholders to build consensus and drive company-wide alignment
Desired Qualifications
  • Significant plus: Experience with infrastructure for ML Ops (model training, deployment, monitoring)

Red Cell Partners is an incubation firm that builds technology-led companies aimed at quickly reaching scale in healthcare and national security. It supports ventures by developing tools and solutions designed to move advanced technologies from concept to market, addressing national priorities. Its approach combines technical development, mentorship, and strategic resources to turn promising ideas into deployable products. Unlike general accelerators, Red Cell focuses on mission-driven, defense-aligned projects with the goal of solving urgent public needs. The company’s objective is to bring practical, impactful innovations to market that strengthen national health and security capabilities.

Company Size

51-200

Company Stage

N/A

Total Funding

$494.5M

Headquarters

New York City, New York

Founded

2020

Simplify Jobs

Simplify's Take

What believers are saying

  • Raised $91M for RCIF I to fund incubations through early-stage rounds.
  • Hired Sean O'Keefe as deputy CTO from Google and Function Health.
  • Opened Incubation Fund II in August 2025 for healthcare and security scaling.

What critics are saying

  • UnitedHealth crushes Crux using Optum's $1B Rally revenue to undercut pricing.
  • AWS reclaims Sridharan, launches agentic platforms starving Trase DoN contracts.
  • Claros obsoletes Trase edge AI via General Catalyst-funded energy tools.

What makes Red Cell Partners unique

  • Red Cell incubates tech-led companies in healthcare, cyber, and national security.
  • Launched Crux in 2024 for affordable QoL medications via employer benefits.
  • Deployed Trase in 2024 for agentic AI in regulated industries like defense.

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Benefits

Health Insurance

Dental Insurance

Vision Insurance

Unlimited Paid Time Off

Flexible Work Hours

Remote Work Options

Parental Leave

Company News

Axios
Mar 19th, 2026
Claros raises $30M seed to cut data centre energy waste

Claros, a startup developing technology to minimise energy waste at data centres, has closed a $30 million seed round co-led by General Catalyst and Red Cell Partners. Systemiq Capital, Aero X Ventures and Trenches Capital also participated as new and existing investors.

Yahoo Finance
Mar 12th, 2026
Red Cell Partners appoints ex-Google and Function Health veteran Sean O'Keefe as deputy CTO

Red Cell Partners has appointed Sean O'Keefe as Deputy Chief Technology Officer. O'Keefe will oversee technology strategy implementation, daily engineering operations and manage the firm's engineering teams. O'Keefe previously served as Senior Vice President of Engineering at Function Health, where he was the first engineering hire and led development of a secure health data platform and generative AI platform. Earlier in his career, he worked at Google Research as a Senior Software Engineer, leading the TensorFlow Model Remediation Library focused on AI safety and bias mitigation. A former Green Beret in the 10th Special Forces Group, O'Keefe also worked at Bridgewater Associates conducting quantitative research. Red Cell Partners is a venture studio building technology companies in healthcare, cyber and national security sectors.

Evolve Security
Feb 25th, 2026
Evoke Security Raises $4M Pre-Seed Round to Secure the Agentic Workforce - Evoke Security

Evoke empowers organizations to deploy AI with confidence. Our platform surfaces and secures risks at the agentic layer.

Red Cell Partners
Jan 19th, 2026
Valinor | Red Cell Partners

Valinor provides a go-to-market engine for those building products for defense, the broader U.S. Government, and our allies.

PR Newswire
Jan 8th, 2026
Valinor Enterprises: $85 Million Raised to Scale New Operating Model for Defense

/PRNewswire/ -- Valinor Enterprises, an operational holding company for defense and government technology, today announced it has raised $54 million in Series...

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