Job Description
The Nonclinical Drug Safety (NDS) division at our company is seeking a motivated and talented in vitro pharmacologist/physiologist with experience in cardiovascular de-risking to join our Safety & Exploratory Pharmacology group.
The Safety & Exploratory Pharmacology deparment (SEP) collaborates with our discovery research, preclinical, and clinical development partners to identify and develop effective, safe therapeutics. To that end, SEP utilizes a purposeful blend of standard screening tools, regulatory-enabling assays, fit for purpose capabilities and forward-looking innovative solutions to understand potential major organ system pharmacodynamic risk and influence drug development strategy.
To enhance that mission, we are looking for a PhD level individual contributor that will complement existing areas, expand the team’s expertise, help drive future innovation, and influence the external scientific and regulatory community. The successful candidate will have demonstrated experience in areas detailed below and will possess the attributes and interest to expand their career toward a broader strategic Nonclinical Drug Safety role. This could include development toward future opportunities in management/leadership roles within SEP and/or as the nonclinical safety lead on discovery or clinical development programs.
Education:
PhD with 6+ years relevant post-degree experience in the development, execution and interpretation of in vitro exploratory or regulated nonclinical safety pharmacology/toxicology models.
Required Experience and Skills:
Ability to work both within teams as a contributor or as a team lead to drive collaborations across departments that deliver current needs and future capabilities.
Experience in ion channel electrophysiology and its practical applications to standard screening and investigative models (ex: over-expressing cells, semi-automated platforms) to drive off target screening or enhanced mechanistic understanding of effects of major organ systems.
Development and/or utilization of exploratory hIPSC-derived models (plate-based or ”organ-on-a-chip")- or microphysiologic systems to enable issue-driven resolution and complement preclinical candidate selection and development,
and/or
Experience either as a study director or contributing scientist for studies conducted under Good Laboratory Practices (GLP) that utilize common nonclinical in vitro test systems (e.g., best practice in vitro studies outlined in ICH E14 / S7B Q&A).
Preferred Experience and Skills:
Hands-on experience on patch clamp techniques and/or utilizing microelectrode arrays, impedance or imaging as readouts.
Willingness and ability to investigate, develop and implement new technologies and capabilities to improve existing techniques and assays.
Prior experience working in a multidisciplinary environment within the Pharmaceutical Industry, Regulatory Agencies, or Academic Institutions.
Willingness to influence safety pharmacology science and the broader regulatory landscape through active participation in external consortiums, publications, and presentations at key scientific conferences.
Experience or familiarity with biostatistics, programming, and/or data visualization tools.
Experience in other safety pharmacology core areas (e.g., in vitro neuronal models to assess hyperexcitability risks)
#EligibleforERP
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Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace.All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics.For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
Not Indicated
Valid Driving License:
No
Hazardous Material(s):
OEB5
Job Posting End Date:
12/11/2024
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
