Senior Research Associate 3

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The University of Miami/UHealth Department of SCCC has an exciting opportunity for a Full Time Sr. Research Associate 3 to work at the UHealth Medical Campus in Miami, FL.

CORE SUMMARY

The Sr. Research Associate 3conducts highly specialized and complex research in support of the division’s research goals and objectivesand assumes responsibility for the successful operations of the laboratory. The incumbent also supervises the activities of all laboratory staff and users and serves as subject matter expert and mentor to less experienced staff.

CORE RESPONSIBILITIES
1. Contributes to basic and applied research activities by collecting and analyzing data.
2. Understands and interprets research protocols and procedures.
3. Maintains an overview of relevant research findings.
4. Ensures all research is undertaken according to good research practice.
5. Designs, evaluates, and implements methods and protocols for assigned research projects.
6. Recommends purchase of new equipment for research projects.
7. Writes scientific articles and manuscripts for publication and presentation.
8. Oversees and ensures the safe handling of radioactive and hazardous materials.
9. Prepares analytical reports relative to research data.
10. Adheres to University and unit-level policies and procedures and safeguards University asse

This list of duties and responsibilities is not intended to be all-inclusive and may be expanded to include other duties or responsibilities as necessary.

CORE QUALIFICATIONS
Education:
Master’s Degree in relevant field

Experience:
Minimum 3 years of relevant experience

knowledge, Skills and Attitudes:
• Skill in collecting, organizing, and analyzing data.
• Ability to recognize, analyze, and solve a variety of problems.
• Ability to exercise sound judgment in making critical decisions

Department Specific Functions

This individual will work in the Division of Transplant and Cell Therapy (TCT) Research Laboratory to support preclinical and translational research.  In Green Lab, we study mechanisms of relapse and resistance to existing cellular therapy approaches, especially CAR T cells. The major goal of our lab is to generate preclinical data for clinical translation.   Relevant experience in immunology, cell biology, molecular biology or a closely related field is highly required. Under the direction of the Principal Investigator, coordinate the daily operations of the laboratory, provide training for staff, ensure laboratory is properly equipped and equipment is properly maintained, and all safety and compliance regulations are in place across the laboratory. Administrative duties include responsibility for maintaining reagent, chemical and supply; selection and ordering of supplies; create and maintain protocols for staff to follow, safety and compliance training and certification for all lab staff and appropriate record keeping. Oversee and ensure effective biospecimen collection, processing, and storage activities including ensuring point-to-point proper coordination of biospecimen collection and processing from time of blood draw to cryopreservation, including providing backup specimen processing. Other duties as assigned by the Director.

Capable of conducting experiments on aseptic cell culture including working on isolation, characterization and assay set up with primary human and murine immune cells, tumor cell lines or primary patient-derived cells. Perform flow cytometry experiments including sample staining and data acquisition by flow cytometry for correlative studies of transplantation and cell therapy research.  Works on production, maintenance and cryopreservation of CAR T cells, in vitro (co-culture assays) conducts genetic engineering techniques that includes PCR, cloning, gene editing of primary immune cells using state of art technologies like CRISPR/TALEN, viral transduction and library preparations. Works on immunological assays that includes multiplex assays ELISA, ELISPOT and Western blotting. Works with mouse models of cancer after appropriate training per institutional guidelines, tissue dissection, primary tissue culture. Assists in Phase I clinical trial related sample receipt, handling and documentation with appropriate training and under supervision. Records and summarizes research data generated from experiments, prepare figures and analyze for presentation and publications. Experience in using Prism, Flow Jo, Microsoft Office is important. Technical training will be provided, and the successful candidate must be able to demonstrate new skills if necessary.

Department Specific Qualifications

Experience: Experience in flow cytometry, immune cell processing, and immune assays required. 5+ years' experience working in an immunology-based research environment preferred.  Qualified individuals without advanced degrees are also encouraged to apply as relevant experience is most critical (position may be downgraded to allow those with appropriate experience to be hired).

Knowledge, Skills and Attitudes:

• Flow Cytometry sample prep, data acquisition and data analysis
• Molecular Biology-Immunology lab techniques
• Capable of working with animals
• Organized, detail oriented, excellent people and communication skills, and knowledge of UM medical school research environment.

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The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

The University of Miami is an Equal Opportunity Employer - Females/Minorities/Protected Veterans/Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here for additional information.

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